Influence of melatonin supplementation on tissue response of endodontic sealers in Wistar rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAlagoas Federal University (UFAL)-
Autor(es): dc.creatorde Oliveira, Pedro Henrique Chaves-
Autor(es): dc.creatorda Silva Rodrigues, Michael Júnio-
Autor(es): dc.creatorda Silva, Cristiane Cantiga-
Autor(es): dc.creatorde Barros Moraes Cardoso, Carolina-
Autor(es): dc.creatorFaria, Flávio Duarte-
Autor(es): dc.creatorCosme-Silva, Leopoldo-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorGomes-Filho, João Eduardo-
Autor(es): dc.creatorSivieri-Araújo, Gustavo-
Autor(es): dc.creatorCintra, Luciano Tavares Angelo-
Data de aceite: dc.date.accessioned2025-08-21T19:48:30Z-
Data de disponibilização: dc.date.available2025-08-21T19:48:30Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10266-024-00982-6-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305223-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305223-
Descrição: dc.descriptionObjective: This study evaluated the influence of melatonin supplementation on tissue’s response of endodontic sealers in Wistar rats. Methodology: Forty-eight rats received subcutaneous implants of four polyethylene tubes: one empty (control) and three filled with endodontic sealers (AH Plus, Endofill and Sealapex). Half of the animals were supplemented with melatonin (ME) and the remaining treated with water (WA) for 15 days before the implantation until euthanasia, forming the groups: control-WA, AH Plus-WA, Endofill-WA, Sealapex-WA, Control-ME, AH Plus-ME, Endofill-ME and Sealapex-ME. After 5, 15 and 30 days, (n = 8) tubes were removed and evaluated in H&E., immunohistochemistry, PSR, VK and POL. The results were statistically analyzed (p < 0.05). Results: In animals treated with water, Endofill-WA evoked more intense inflammatory infiltrate compared to AH Plus-WA and Control-WA in a 30-day period (p < 0.05). In animals supplemented with melatonin, there was any difference among endodontic sealers' response in any period of analysis (p > 0.05). Comparing the individual response of each sealer, over a 30-day period, Endofill-ME and Sealapex-ME showed less inflammatory infiltrate compared to Endofill-WA and Sealapex-WA, respectively (p < 0.05). Immunostaining for IL-6 and TNF-α was less intense for all groups in animals supplemented with melatonin, in most periods, except for the Endofill sealer (p < 0.05). Furthermore, Endofill-ME at 5 days and AH-Plus-ME at 30 days showed a higher percentage of mature collagen fibers compared to the Endofill-WA and AH Plus-WA, respectively (p < 0.05). Positive structures for von Kossa staining and birefringent to polarized light were observed only for Sealapex-WA and Sealapex-ME in all periods. Conclusions: It can be concluded that melatonin influences the tissue response to endodontic sealers, modulating the inflammatory and reparative process.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartament of Endodontics School of Dentistry Alagoas Federal University (UFAL), AL-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 24713-7-
Formato: dc.format358-371-
Idioma: dc.languageen-
Relação: dc.relationOdontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndodontic sealers-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMelatonin-
Palavras-chave: dc.subjectMineralization-
Palavras-chave: dc.subjectTissue response-
Título: dc.titleInfluence of melatonin supplementation on tissue response of endodontic sealers in Wistar rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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