HOXA1 3′UTR Methylation Is a Potential Prognostic Biomarker in Oral Squamous cell Carcinoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorA.C. Camargo Cancer Center-
Autor(es): dc.contributorLatin American Cooperative Oncology Group-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorCancer Institute of the State of São Paulo (ICESP)-
Autor(es): dc.contributorUniversity Hospital of Southern Denmark-
Autor(es): dc.contributorUniversity of Southern Denmark-
Autor(es): dc.creatorSorroche, Bruna Pereira-
Autor(es): dc.creatorMiranda, Keila Cristina-
Autor(es): dc.creatorBeltrami, Caroline Moraes-
Autor(es): dc.creatorArantes, Lidia Maria Rebolho Batista-
Autor(es): dc.creatorKowalski, Luiz Paulo-
Autor(es): dc.creatorMarchi, Fabio Albuquerque-
Autor(es): dc.creatorRogatto, Silvia Regina-
Autor(es): dc.creatorAlmeida, Janete Dias-
Data de aceite: dc.date.accessioned2025-08-21T21:26:53Z-
Data de disponibilização: dc.date.available2025-08-21T21:26:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cancers16050874-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305109-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305109-
Descrição: dc.descriptionBackground: HOXA1 is a prognostic marker and a potential predictive biomarker for radioresistance in head and neck tumors. Its overexpression has been associated with promoter methylation and a worse prognosis in oral squamous cell carcinoma (OSCC) patients. However, opposite outcomes are also described. The effect of the methylation of this gene on different gene regions, other than the promoter, remains uncertain. We investigated the methylation profile at different genomic regions of HOXA1 in OSCC and correlated differentially methylated CpG sites with clinicopathological data. Methods: The HOXA1 DNA methylation status was evaluated by analyzing data from The Cancer Genome Atlas and three Gene Expression Omnibus datasets. Significant differentially methylated CpG sites were considered with a |∆β| ≥ 0.10 and a Bonferroni-corrected p-value < 0.01. Differentially methylated CpGs were validated by pyrosequencing using two independent cohorts of 15 and 47 OSCC patients, respectively. Results: Compared to normal tissues, we found significantly higher DNA methylation levels in the 3′UTR region of HOXA1 in OSCC. Higher methylation levels in tumor samples were positively correlated with smoking habits and patients’ overall survival. Conclusions: Our findings suggest that HOXA1 gene body methylation is a promising prognostic biomarker for OSCC with potential clinical applications in patient monitoring.-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionInternational Research Center A.C. Camargo Cancer Center-
Descrição: dc.descriptionHead and Neck Surgery and Otorhinolaryngology Department AC Camargo Cancer Center Latin American Cooperative Oncology Group-
Descrição: dc.descriptionHead and Neck Surgery Department and LIM 28 University of São Paulo Medical School-
Descrição: dc.descriptionCenter for Translational Research in Oncology Cancer Institute of the State of São Paulo (ICESP)-
Descrição: dc.descriptionClinical Hospital of the University of Sao Paulo Medical School (HCFMUSP)-
Descrição: dc.descriptionDepartment of Clinical Genetics University Hospital of Southern Denmark-
Descrição: dc.descriptionInstitute of Regional Health Research University of Southern Denmark-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationCancers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDNA methylation-
Palavras-chave: dc.subjecthead and neck cancer-
Palavras-chave: dc.subjectHOXA1-
Palavras-chave: dc.subjectoral squamous cell carcinoma-
Palavras-chave: dc.subjecttumor suppressor gene-
Título: dc.titleHOXA1 3′UTR Methylation Is a Potential Prognostic Biomarker in Oral Squamous cell Carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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