Beyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Fed Paraiba-
Autor(es): dc.contributorTrials Pesquisa & Desenvolvimento-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTriplet Biotechnol Solut-
Autor(es): dc.creatorOliveira, Andressa Feitosa Bezerra de-
Autor(es): dc.creatorCosta, Bianne Maria de Melo-
Autor(es): dc.creatorForte, Anderson Gomes-
Autor(es): dc.creatorSousa, Elizabeth Barreto Galvao de-
Autor(es): dc.creatorNunes, Vitoria Regia Rolim-
Autor(es): dc.creatorAndrade, Arthur Felipe de Brito-
Autor(es): dc.creatorCunha, Juliellen Luiz da-
Autor(es): dc.creatorFernandes, Nayanna Lana Soares-
Autor(es): dc.creatorPereira, Ana Maria Barros Chaves-
Autor(es): dc.creatorVilhena, Fabiano Vieira-
Autor(es): dc.creatorD'Alpino, Paulo Henrique Perlatti-
Autor(es): dc.creatorSampaio, Fabio Correia-
Data de aceite: dc.date.accessioned2025-08-21T19:30:53Z-
Data de disponibilização: dc.date.available2025-08-21T19:30:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/oral4040045-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305060-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305060-
Descrição: dc.descriptionThis in vitro study evaluated the protective effect of an Si-containing toothpaste associated with different fluoride concentrations by reducing the depth of the demineralized lesions in dentin after cariogenic pH cycling. Methods: Sixty bovine dentin blocks (4 x 4 x 2 mm) were randomly assigned into five groups (n = twelve/group): RGS1 (Si toothpaste with 1450 ppm F), RGS2 (Si toothpaste with 1100 ppm F), RGS3 (fluoride-free Si toothpaste), negative control (NC) (fluoride-free toothpaste), and positive control (PC) (1450 ppm F toothpaste). The specimens underwent a three-day pH cycling model simulating the oral environment with twice-daily brushing. The mineral loss (Delta F) and lesion depth (Delta Fmax) were assessed using quantitative light-induced fluorescence (QLF), and scanning electron microscopy (SEM) provided a morphological analysis. Elemental analyses were performed with an energy-dispersive X-ray spectrometer (EDS). ANOVA and Tukey's test were used for the data analysis (alpha = 5%). Results: EDS confirmed the Si in the toothpaste formulations. The groups treated with fluoride silicon toothpastes (RGS1, RGS2) had significantly reduced mineral loss and lesion depth compared to the PC group. The NC group exhibited the greatest mineral loss and lesion depth. SEM images revealed occluded superficial dentin tubules and a protective mineral layer in the groups treated with Si toothpaste, whereas no deposition (NC group) or limited mineral deposition (PC group) was observed in the control groups. Conclusions: The findings suggest that the Si toothpastes favored protection against dentin demineralization, even at a lower concentration or free of fluoride, with dentin tubule occlusion, thus representing a promising oral care product over traditional fluoride toothpastes.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPostgraduate Program in Dentistry (PPGO)-
Descrição: dc.descriptionUniv Fed Paraiba, Hlth Sci Ctr, Dept Morphol, BR-58051900 Joao Pessoa, Brazil-
Descrição: dc.descriptionUniv Fed Paraiba, Postgrad Dent Program, BR-58051900 Joao Pessoa, Brazil-
Descrição: dc.descriptionUniv Fed Paraiba, Dent Sch, Inst Sci Initiat Scholarship Program, BR-58051900 Joao Pessoa, Brazil-
Descrição: dc.descriptionTrials Pesquisa & Desenvolvimento, BR-01236030 Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ Unesp, Sch Sci, BR-17033360 Sao Paulo, Brazil-
Descrição: dc.descriptionTriplet Biotechnol Solut, BR-17010270 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Paraiba, Hlth Sci Ctr, Dept Clin & Community Dent, BR-58051900 Joao Pessoa, Brazil-
Descrição: dc.descriptionSao Paulo State Univ Unesp, Sch Sci, BR-17033360 Sao Paulo, Brazil-
Formato: dc.format578-588-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationOral-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectdental caries-
Palavras-chave: dc.subjectbiomimetics-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectsilicon-
Palavras-chave: dc.subjectremineralization-
Palavras-chave: dc.subjectdentin-
Título: dc.titleBeyond Fluoride: Exploring Silicon's Potential for Dental Repair and Caries Prevention-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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