Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculty of Medicine of São José do Rio Preto (FAMERP)-
Autor(es): dc.contributorUTHealth-
Autor(es): dc.creatorde Almeida Chuffa, Luiz Gustavo-
Autor(es): dc.creatorSeiva, Fábio Rodrigues Ferreira-
Autor(es): dc.creatorSilveira, Henrique S.-
Autor(es): dc.creatorCesário, Roberta Carvalho-
Autor(es): dc.creatorda Silva Tonon, Karolina-
Autor(es): dc.creatorSimão, Vinicius Augusto-
Autor(es): dc.creatorZuccari, Debora Aparecida P. C.-
Autor(es): dc.creatorReiter, Russel J.-
Data de aceite: dc.date.accessioned2025-08-21T23:45:33Z-
Data de disponibilização: dc.date.available2025-08-21T23:45:33Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jcp.31383-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305011-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305011-
Descrição: dc.descriptionThe endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its function can lead to various diseases. ER stress triggers an adaptive response called the unfolded protein response (UPR), which can either restore cellular homeostasis or induce cell death. Melatonin, a safe and multifunctional compound, shows promise in controlling ER stress and could be a valuable therapeutic agent for managing the UPR. By regulating ER and mitochondrial functions, melatonin helps maintain cellular homeostasis via reduction of oxidative stress, inflammation, and apoptosis. Melatonin can directly or indirectly interfere with ER-associated sensors and downstream targets of the UPR, impacting cell death, autophagy, inflammation, molecular repair, among others. Crucially, this review explores the mechanistic role of melatonin on ER stress in various diseases including liver damage, neurodegeneration, reproductive disorders, pulmonary disease, cardiomyopathy, insulin resistance, renal dysfunction, and cancer. Interestingly, while it alleviates the burden of ER stress in most pathological contexts, it can paradoxically stimulate ER stress in cancer cells, highlighting its intricate involvement in cellular homeostasis. With numerous successful studies using in vivo and in vitro models, the continuation of clinical trials is imperative to fully explore melatonin's therapeutic potential in these conditions.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Bioscences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Molecular Biology Faculty of Medicine of São José do Rio Preto (FAMERP), São Paulo-
Descrição: dc.descriptionDepartment of Cellular and Structural Biology UTHealth-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Bioscences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2021/12971-7-
Descrição: dc.descriptionCNPq: 306117/2023-1-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cellular Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectapoptosis-
Palavras-chave: dc.subjectcell fate-
Palavras-chave: dc.subjectendoplasmic reticulum stress-
Palavras-chave: dc.subjectmelatonin-
Palavras-chave: dc.subjectpathological disorders-
Título: dc.titleMelatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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