Histological Bone-Healing Evaluation of Critical-Size Defects Filled with β-Tricalcium Phosphate in Rat Tibiae

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity Center São Lucas-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversity Coimbra-
Autor(es): dc.creatorVasques, Ana Maria Veiga-
Autor(es): dc.creatorBueno, Carlos Roberto Emerenciano-
Autor(es): dc.creatorGuimarães, Maria Rosa Felix de Souza Gomide-
Autor(es): dc.creatorValentim, Diego-
Autor(es): dc.creatorda Silva, Ana Cláudia Rodrigues-
Autor(es): dc.creatorBenetti, Francine-
Autor(es): dc.creatorSantos, João Miguel Marques-
Autor(es): dc.creatorCintra, Luciano Tavares Angelo-
Autor(es): dc.creatorDezan Junior, Eloi-
Data de aceite: dc.date.accessioned2025-08-21T16:37:42Z-
Data de disponibilização: dc.date.available2025-08-21T16:37:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/app14093821-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304948-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304948-
Descrição: dc.descriptionBone defects may be a result of different pathologies and represent a challenge in different fields of dentistry. Techniques for the correction of bone defects involving the use of several types of grafts have been proposed. This study evaluated bone repair in rat tibiae after surgically created critical-size defects were filled with β-tricalcium phosphate (RTR®, Septodont, FR). Critical-size bone defects were created in the tibiae of 32 male Wistar rats, which were divided into four groups (n = 8): Control 30 days, Control 90 days, RTR® 30 days, and RTR® 90 days. After the experimental period, the animals were euthanized and specimens were collected, embedded in paraffin, serially cut, and stained with hematoxylin and eosin to evaluate the inflammatory and repair response. Two parameters were analyzed: neoformed bone tissue areas (NBA) and neoformed cortical areas (NCA). Statistical analysis was performed by ANOVA and Tukey’s test (p < 0.05). The RTR® group demonstrated superior bone healing compared with the control group in both analyzed parameters (NBA and NCA), with repair of the cortical bone and bone-tissue formation in the central region of the defect, which showed partial repair in the defect area (p < 0.05). RTR® enhanced bone neoformation in the adopted experimental model and may be a useful biomaterial to boost healing in cases of critical-size bone defects.-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionEndodontic Section Department of Dentistry School of Dentistry University Center São Lucas, RO-
Descrição: dc.descriptionEndodontic Section Department of Restorative Dentistry Faculty of Dentistry Federal University of Minas Gerais (UFMG), MG-
Descrição: dc.descriptionInstitute of Endodontics Faculty of Medicine University Coimbra-
Descrição: dc.descriptionEndodontic Section Department of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationApplied Sciences (Switzerland)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectbone substitute-
Palavras-chave: dc.subjectRTR®-
Palavras-chave: dc.subjectβ-tricalcium phosphate-
Título: dc.titleHistological Bone-Healing Evaluation of Critical-Size Defects Filled with β-Tricalcium Phosphate in Rat Tibiae-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.