Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorEmory University School of Medicine-
Autor(es): dc.contributorFox Chase Cancer Center-
Autor(es): dc.creatorCamargo, Ana CL.-
Autor(es): dc.creatorConstantino, Flávia B.-
Autor(es): dc.creatorSantos, Sergio AA.-
Autor(es): dc.creatorColombelli, Ketlin T.-
Autor(es): dc.creatorPortela, Luiz MF.-
Autor(es): dc.creatorFioretto, Matheus N.-
Autor(es): dc.creatorBarata, Luísa A.-
Autor(es): dc.creatorValente, Guilherme T.-
Autor(es): dc.creatorMoreno, Carlos S.-
Autor(es): dc.creatorJustulin, Luis A.-
Data de aceite: dc.date.accessioned2025-08-21T21:01:27Z-
Data de disponibilização: dc.date.available2025-08-21T21:01:27Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2023.112102-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304907-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304907-
Descrição: dc.descriptionAims: The developmental Origins of Health and Disease (DOHaD) concept has provided the framework to assess how early life experiences can shape health and disease throughout the life course. Using a model of maternal exposure to a low protein diet (LPD; 6% protein) during the gestational and lactational periods, we demonstrated changes in the ventral prostate (VP) transcriptomic landscape in young rats exposed to maternal malnutrition. Male offspring Sprague Dawley rats were submitted to maternal malnutrition during gestation and lactation, and they were weighed, and distance anogenital was measured, followed were euthanized by an overdose of anesthesia at 21 postnatal days. Next, the blood and the ventral prostate (VP) were collected and processed by morphological analysis, biochemical and molecular analyses. RNA-seq analysis identified 411 differentially expressed genes (DEGs) in the VP of maternally malnourished offspring compared to the control group. The molecular pathways enriched by these DEGs are related to cellular development, differentiation, and tissue morphogenesis, all of them involved in both normal prostate development and carcinogenesis. Abcg1 was commonly deregulated in young and old maternally malnourished offspring rats, as well in rodent models of prostate cancer (PCa) and in PCa patients. Our results described ABCG1 as a potential DOHaD gene associated with perturbation of prostate developmental biology with long-lasting effects on carcinogenesis in old offspring rats. A better understanding of these mechanisms may help with the discussion of preventive strategies against early life origins of non-communicable chronic diseases.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionLaboratory of Human Genetics Center for Molecular Biology and Genetic Engineering (CBMEG) University of Campinas (UNICAMP), SP-
Descrição: dc.descriptionDepartment of Pathology and Laboratory Medicine and Department of Biomedical Informatics Emory University School of Medicine-
Descrição: dc.descriptionCancer Signaling and Epigenetics Program Fox Chase Cancer Center-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDOHaD-
Palavras-chave: dc.subjectEarly-life carcinogenesis-
Palavras-chave: dc.subjectMaternal malnutrition-
Palavras-chave: dc.subjectProstate development-
Título: dc.titleDeregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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