Current Perspectives of Antifungal Therapy: A Special Focus on Candida auris

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSaveetha Institute of Medical and Technical Sciences (SIMTS)-
Autor(es): dc.contributorBharathidasan University-
Autor(es): dc.creatorGaneshkumar, Arumugam-
Autor(es): dc.creatorMuthuselvam, Manickam-
Autor(es): dc.creatorLima, Patricia Michelle Nagai de-
Autor(es): dc.creatorRajaram, Rajendren-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Data de aceite: dc.date.accessioned2025-08-21T20:52:21Z-
Data de disponibilização: dc.date.available2025-08-21T20:52:21Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof10060408-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304898-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304898-
Descrição: dc.descriptionCandida auris is an emerging Candida sp. that has rapidly spread all over the world. The evidence regarding its origin and emerging resistance is still unclear. The severe infection caused by this species results in significant mortality and morbidity among the elderly and immunocompromised individuals. The development of drug resistance is the major factor associated with the therapeutic failure of existing antifungal agents. Previous studies have addressed the antifungal resistance profile and drug discovery for C. auris. However, complete coverage of this information in a single investigation is not yet available. In this review, we have mainly focused on recent developments in therapeutic strategies against C. auris. Based on the available information, several different approaches were discussed, including existing antifungal drugs, chemical compounds, essential oils, natural products, antifungal peptides, immunotherapy, antimicrobial photodynamic therapy, drug repurposing, and drug delivery systems. Among them, synthetic chemicals, natural products, and antifungal peptides are the prime contributors. However, a limited number of resources are available to prove the efficiency of these potential therapies in clinical usage. Therefore, we anticipate that the findings gathered in this review will encourage further in vivo studies and clinical trials.-
Descrição: dc.descriptionOffice of Naval Research Global-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Materials Physics Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMTS), Tamil Nadu-
Descrição: dc.descriptionDepartment of Biotechnology Bharathidasan University, Tamil Nadu-
Descrição: dc.descriptionDepartment of Marine Science Bharathidasan University, Tamil Nadu-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionOffice of Naval Research Global: N62909-20-1-2034-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal essential oil-
Palavras-chave: dc.subjectantifungal natural products-
Palavras-chave: dc.subjectantifungal peptides-
Palavras-chave: dc.subjectantifungal therapy-
Palavras-chave: dc.subjectCandida auris-
Título: dc.titleCurrent Perspectives of Antifungal Therapy: A Special Focus on Candida auris-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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