Estrogen Deficiency Impairs Osseointegration in Hypertensive Rats Even Treated with Alendronate Coated on the Implant Surface

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorScience and Technology of São Paulo (IFSP)-
Autor(es): dc.creatorMulinari-Santos, Gabriel-
Autor(es): dc.creatordos Santos, Jaqueline Silva-
Autor(es): dc.creatorKitagawa, Igor Lebedenco-
Autor(es): dc.creatorde Souza Batista, Fábio Roberto-
Autor(es): dc.creatorBotacin, Paulo Roberto-
Autor(es): dc.creatorAntoniali, Cristina-
Autor(es): dc.creatorLisboa-Filho, Paulo Noronha-
Autor(es): dc.creatorOkamoto, Roberta-
Data de aceite: dc.date.accessioned2025-08-21T18:06:33Z-
Data de disponibilização: dc.date.available2025-08-21T18:06:33Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb14090471-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304844-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304844-
Descrição: dc.descriptionHypertension and estrogen deficiency can affect bone metabolism and therefore increase the risk of osseointegration. Antihypertensive drugs such as losartan not only control blood pressure but also enhance bone healing. In addition, alendronate sodium is widely used to treat postmenopausal osteoporosis. Hence, we evaluated the effect of systemic antihypertensive and local alendronate coted on implants on osseointegration under hypertensive and estrogen-deficiency conditions. A total of 64 spontaneously hypertensive rats (SHRs) treated with losartan were randomly divided according to the estrogen-deficiency induction by ovariectomy (OVX) or not (SHAM), and whether the implant surface was coated with sodium alendronate (ALE) or not, resulting in four groups: SHR SHAM, SHR SHAM ALE, SHR OVX, and SHR OVX ALE. The removal torque, microcomputed tomography, and epifluorescence microscopy were the adopted analyses. The hypertensive and estrogen-deficiency animals presented a lower removal torque even when treated with alendronate on implant surface. The microcomputed tomography revealed a higher bone volume and bone-to-implant contact in the SHRs than the SHR OVX rats. Epifluorescence showed a decreased mineral apposition ratio in the SHR OVX ALE group. The data presented indicate that estrogen deficiency impairs osseointegration in hypertensive rats; in addition, alendronate coated on the implant surface does not fully reverse this impaired condition caused by estrogen deficiency.-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFederal Institute of Education Science and Technology of São Paulo (IFSP), SP-
Descrição: dc.descriptionDepartment of Physics School of Science São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Physics School of Science São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalendronate-
Palavras-chave: dc.subjectbone-
Palavras-chave: dc.subjectlosartan-
Palavras-chave: dc.subjectosseointegration-
Palavras-chave: dc.subjectspontaneously hypertensive rats-
Título: dc.titleEstrogen Deficiency Impairs Osseointegration in Hypertensive Rats Even Treated with Alendronate Coated on the Implant Surface-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.