Peri-implantitis increases the risk of medication-related osteonecrosis of the jaws associated with osseointegrated implants in rats treated with zoledronate

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorLatin American Institute of Dental Research and Education (ILAPEO)-
Autor(es): dc.creatorQuintão Manhanini Souza, Eduardo-
Autor(es): dc.creatorFelipe Toro, Luan-
Autor(es): dc.creatorFranzão Ganzaroli, Vinícius-
Autor(es): dc.creatorde Oliveira Alvarenga Freire, Jéssica-
Autor(es): dc.creatorMatsumoto, Mariza Akemi-
Autor(es): dc.creatorCasatti, Cláudio Aparecido-
Autor(es): dc.creatorTavares Ângelo Cintra, Luciano-
Autor(es): dc.creatorLeone Buchaim, Rogério-
Autor(es): dc.creatorMardegan Issa, João Paulo-
Autor(es): dc.creatorGouveia Garcia, Valdir-
Autor(es): dc.creatorTheodoro, Leticia Helena-
Autor(es): dc.creatorErvolino, Edilson-
Data de aceite: dc.date.accessioned2025-08-21T16:38:03Z-
Data de disponibilização: dc.date.available2025-08-21T16:38:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-023-49647-4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304788-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304788-
Descrição: dc.descriptionThis study evaluated the peri-implant tissues under normal conditions and under the influence of experimental peri-implantitis (EPI) in osseointegrated implants installed in the maxillae of rats treated with oncologic dosage of zoledronate. Twenty-eight senescent female rats underwent the extraction of the upper incisor and placement of a titanium dental implant (DI). After eight weeks was installated a transmucosal healing screw on DI. After nine weeks, the following groups were formed: VEH, ZOL, VEH-EPI and ZOL-EPI. From the 9th until the 19th, VEH and VEH-EPI groups received vehicle and ZOL and ZOL-EPI groups received zoledronate. At the 14th week, a cotton ligature was installed around the DI in VEH-EPI and ZOL-EPI groups to induce the EPI. At the 19th week, euthanasia was performed, and the maxillae were processed so that at the implanted sites were analyzed: histological aspects and the percentage of total bone tissue (PTBT) and non-vital bone tissue (PNVBT), along with TNFα, IL-1β, VEGF, OCN and TRAP immunolabeling. ZOL group presented mild persistent peri-implant inflammation, higher PNVBT and TNFα and IL-1β immunolabeling, but lower for VEGF, OCN and TRAP in comparison with VEH group. ZOL-EPI group exhibited exuberant peri-implant inflammation, higher PNVBT and TNFα and IL-1β immunolabeling when compared with ZOL and VEH-EPI groups. Zoledronate disrupted peri-implant environment, causing mild persistent inflammation and increasing the quantity of non-vital bone tissue. Besides, associated with the EPI there were an exacerbated inflammation and even greater increase in the quantity of non-vital bone around the DI, which makes this condition a risk factor for medication-related osteonecrosis of the jaws.-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Basic and Oral Biology School of Dentistry of Ribeirão Preto University of São Paulo (USP), SP-
Descrição: dc.descriptionLatin American Institute of Dental Research and Education (ILAPEO), PR-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titlePeri-implantitis increases the risk of medication-related osteonecrosis of the jaws associated with osseointegrated implants in rats treated with zoledronate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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