IL-22 Is Deleterious along with IL-17 in Allergic Asthma but Is Not Detrimental in the Comorbidity Asthma and Acute Pneumonia

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGoulart, Amanda-
Autor(es): dc.creatorBoko, Mèdéton Mahoussi Michaël-
Autor(es): dc.creatorMartins, Nubia Sabrina-
Autor(es): dc.creatorGembre, Ana Flávia-
Autor(es): dc.creatorde Oliveira, Rômulo Silva-
Autor(es): dc.creatorPalma-Albornoz, Sandra Patrícia-
Autor(es): dc.creatorBertolini, Thais-
Autor(es): dc.creatorRibolla, Paulo Eduardo Martins-
Autor(es): dc.creatorRamalho, Leandra Naira Zambelli-
Autor(es): dc.creatorFraga-Silva, Thais Fernanda de Campos-
Autor(es): dc.creatorBonato, Vânia Luiza Deperon-
Data de aceite: dc.date.accessioned2025-08-21T19:17:57Z-
Data de disponibilização: dc.date.available2025-08-21T19:17:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms241310418-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304746-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304746-
Descrição: dc.descriptionThere is evidence that IL-22 and IL-17 participate in the pathogenesis of allergic asthma. To investigate the role of IL-22, we used IL-22 deficient mice (IL-22 KO) sensitized and challenged with ovalbumin (OVA) and compared with wild type (WT) animals exposed to OVA. IL-22 KO animals exposed to OVA showed a decreased number and frequency of eosinophils, IL-5 and IL-13 in the airways, reduced mucus production and pulmonary inflammation. In addition, IL-22 KO animals exhibited a decreased percentage and number of lung CD11c+CD11b+ cells and increased apoptosis of eosinophils. Th17 cell transfer generated from IL-22 KO to animals previously sensitized and challenged with OVA caused a reduction in eosinophil frequency and number in the airways compared to animals transferred with Th17 cells generated from WT mice. Therefore, IL-22 is deleterious with concomitant secretion of IL-17. Our findings show a pro-inflammatory role for IL-22, confirmed in a model of allergen-free and allergen-specific immunotherapy. Moreover, during the comorbidity asthma and pneumonia that induces neutrophil inflammation, IL-22 was not detrimental. Our results show that targeting IL-22 would negatively affect the survival of eosinophils, reduce the expansion or migration of CD11c+CD11b+ cells, and negatively regulate allergic asthma.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBasic and Applied Immunology Program Ribeirao Preto Medical School University of Sao Paulo, Sao Paulo-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Ribeirao Preto Medical School University of Sao Paulo, Sao Paulo-
Descrição: dc.descriptionBiotechnology Institute Sao Paulo State University, Sao Paulo-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Ribeirao Preto Medical School University of Sao Paulo, Sao Paulo-
Descrição: dc.descriptionBiotechnology Institute Sao Paulo State University, Sao Paulo-
Descrição: dc.descriptionFAPESP: 2019/09881-6-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectapoptosis-
Palavras-chave: dc.subjectasthma-
Palavras-chave: dc.subjectdendritic cell-
Palavras-chave: dc.subjecteosinophil-
Palavras-chave: dc.subjectIL-17-
Palavras-chave: dc.subjectIL-22-
Título: dc.titleIL-22 Is Deleterious along with IL-17 in Allergic Asthma but Is Not Detrimental in the Comorbidity Asthma and Acute Pneumonia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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