Plasma metabolic profile reveals signatures of maternal health during gestational hypertension and preeclampsia without and with severe features

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Aveiro-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorKaihara, Julyane N.S.-
Autor(es): dc.creatorde Moraes, Fabio Rogerio-
Autor(es): dc.creatorNunes, Priscila Rezeck-
Autor(es): dc.creatorAlves, Marco G.-
Autor(es): dc.creatorCavalli, Ricardo C.-
Autor(es): dc.creatorTasic, Ljubica-
Autor(es): dc.creatorSandrim, Valeria Cristina-
Data de aceite: dc.date.accessioned2025-08-21T19:20:14Z-
Data de disponibilização: dc.date.available2025-08-21T19:20:14Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0314053-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304686-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304686-
Descrição: dc.descriptionPreeclampsia, a pregnancy-specific syndrome, poses substantial risks to maternal and neonatal health, particularly in cases with severe features. Our study focuses on evaluating the impact of low molecular weight metabolites on the intricate mechanisms and pathways involved in the pathophysiology of preeclampsia when severe features are present. We aim to pinpoint the distinct metabolomic profile in maternal plasma during pregnancies affected by hypertensive disorders and to correlate the metabolite levels with the clinical characteristics of the study cohort. A total of 173 plasma samples were collected, comprising 36 healthy pregnant women (HP), 52 patients with gestational hypertension (GH), 43 with preeclampsia without (PE–), and 42 with severe features (PE+). Nuclear magnetic resonance spectroscopy and metabolite identification were conducted to establish the metabolomic profiles. Univariate and chemometric analyses were conducted using MetaboAnalyst, and correlations were performed using GraphPad Prism. Our study unveils distinct metabolomic profiles differentiating HP women, patients featuring GH, and patients with PE–and PE+. Our analysis highlights an increase in acetate, N,N-dimethylglycine, glutamine, alanine, valine, and creatine levels in the PE+ group compared to the HP and GH groups. The PE+ group exhibited higher concentrations of N,N-dimethylglycine, glutamine, alanine, and valine compared to the PE–group. Moreover, elevated levels of specific metabolites, including N,N-dimethylglycine, alanine, and valine, were associated with increased blood pressure, worse obstetric outcomes, and poorer end-organ function, particularly renal and hepatic damage. Metabolomic analysis of PE+ individuals indicates heightened disturbances in nitrogen metabolism, methionine, and urea cycles. Additionally, the exacerbated metabolic disturbance may have disclosed renal impairment and hepatic dysfunction, evidenced by elevated levels of creatine and alanine. These findings not only contribute novel insights but also provide a more comprehensive understanding of the pathophysiological mechanisms at play in cases of PE+.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics Institute of Biosciences Languages and Exact Sciences Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Biomedicine Department of Medical Science (iBiMED) University of Aveiro-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Organic Chemistry Institute of Chemistry State University of Campinas (UNICAMP), SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics Institute of Biosciences Languages and Exact Sciences Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2018/24069-3-
Descrição: dc.descriptionFAPESP: 2019/07230-8-
Descrição: dc.descriptionFAPESP: 2021/12010-7-
Descrição: dc.descriptionFAPESP: 2023/08897-1-
Descrição: dc.descriptionCNPq: 308079/2021-3-
Descrição: dc.descriptionCNPq: 308504/2021-6-
Descrição: dc.descriptionCAPES: 88887.806462/2023-00-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia: UIDB/04501/2020-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia: UIDP/04501/2020-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titlePlasma metabolic profile reveals signatures of maternal health during gestational hypertension and preeclampsia without and with severe features-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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