Photodynamic Therapy as a Novel Therapeutic Modality Applying Quinizarin-Loaded Nanocapsules and 3D Bioprinting Skin Permeation for Inflammation Treatment

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorScience and Technology (IFSP)-
Autor(es): dc.contributorUniversity of Birmingham-
Autor(es): dc.creatordo Amaral, Stéphanie R.-
Autor(es): dc.creatorAmantino, Camila F.-
Autor(es): dc.creatorAtanasov, Aleksandar-
Autor(es): dc.creatorSousa, Stefanie Oliveira-
Autor(es): dc.creatorMoakes, Richard-
Autor(es): dc.creatorOliani, Sonia Maria-
Autor(es): dc.creatorGrover, Liam M.-
Autor(es): dc.creatorPrimo, Fernando L.-
Data de aceite: dc.date.accessioned2025-08-21T22:33:59Z-
Data de disponibilização: dc.date.available2025-08-21T22:33:59Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph17091169-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304671-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304671-
Descrição: dc.descriptionSkin inflammation associated with chronic diseases involves a direct role of keratinocytes in its immunopathogenesis, triggering a cascade of immune responses. Despite this, highly targeted treatments remain elusive, highlighting the need for more specific therapeutic strategies. In this study, nanocapsules containing quinizarin (QZ/NC) were developed and evaluated in an in vitro model of keratinocyte-mediated inflammation, incorporating the action of photodynamic therapy (PDT) and analyzing permeation in a 3D skin model. Comprehensive physicochemical, stability, cytotoxicity, and permeation analyses of the nanomaterials were conducted. The nanocapsules demonstrated desirable physicochemical properties, remained stable throughout the analysis period, and exhibited no spectroscopic alterations. Cytotoxicity tests revealed no toxicity at the lowest concentrations of QZ/NC. Permeation and cellular uptake studies confirmed QZ/NC permeation in 3D skin models, along with intracellular incorporation and internalization of the drug, thereby enhancing its efficacy in drug delivery. The developed model for inducing the inflammatory process in vitro yielded promising results, particularly when the synthesized nanomaterial was combined with PDT, showing a reduction in cytokine levels. These findings suggest a potential new therapeutic approach for treating inflammatory skin diseases.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSão Paulo Federal Institute of Education Science and Technology (IFSP), SP-
Descrição: dc.descriptionSchool of Chemical Engineering University of Birmingham-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: 88887.839000/2023-00-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectnanomedicine-
Palavras-chave: dc.subjectphotodynamic therapy-
Palavras-chave: dc.subjectskin inflammation-
Título: dc.titlePhotodynamic Therapy as a Novel Therapeutic Modality Applying Quinizarin-Loaded Nanocapsules and 3D Bioprinting Skin Permeation for Inflammation Treatment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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