Different bacterial cargo in apoptotic cells drive distinct macrophage phenotypes

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorVanderbilt University Medical Center (VUMC)-
Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.creatorSalina, Ana Carolina Guerta-
Autor(es): dc.creatorde Aquino Penteado, Letícia-
Autor(es): dc.creatorDejani, Naiara Naiana-
Autor(es): dc.creatorSilva-Pereira, Ludmilla-
Autor(es): dc.creatorRaimundo, Breno Vilas Boas-
Autor(es): dc.creatorCorrêa, Gabriel Ferranti-
Autor(es): dc.creatorOliveira, Karen Cristina-
Autor(es): dc.creatorRamalho, Leandra Naira Zambelli-
Autor(es): dc.creatorBoko, Mèdéton Mahoussi Michaël-
Autor(es): dc.creatorBonato, Vânia L. D.-
Autor(es): dc.creatorHenrique Serezani, C.-
Autor(es): dc.creatorMedeiros, Alexandra Ivo-
Data de aceite: dc.date.accessioned2025-08-21T20:29:24Z-
Data de disponibilização: dc.date.available2025-08-21T20:29:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10495-023-01899-1-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304638-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304638-
Descrição: dc.descriptionThe removal of dead cells (efferocytosis) contributes to the resolution of the infection and preservation of the tissue. Depending on the environment milieu, macrophages may show inflammatory (M1) or anti-inflammatory (M2) phenotypes. Inflammatory leukocytes are recruited during infection, followed by the accumulation of infected and non-infected apoptotic cells (AC). Efferocytosis of non-infected AC promotes TGF-β, IL-10, and PGE2 production and the polarization of anti-inflammatory macrophages. These M2 macrophages acquire an efficient ability to remove apoptotic cells that are involved in tissue repair and resolution of inflammation. On the other hand, the impact of efferocytosis of infected apoptotic cells on macrophage activation profile remains unknown. Here, we are showing that the efferocytosis of gram-positive Streptococcus pneumoniae-AC (Sp-AC) or gram-negative Klebsiella pneumoniae-AC (Kp-AC) promotes distinct gene expression and cytokine signature in macrophages. Whereas the efferocytosis of Kp-AC triggered a predominant M1 phenotype in vitro and in vivo, the efferocytosis of Sp-AC promoted a mixed M1/M2 activation in vitro and in vivo in a model of allergic asthma. Together, these findings suggest that the nature of the pathogen and antigen load into AC may have different impacts on inducing macrophage polarization.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionBasic and Applied Immunology Program Ribeirao Preto Medical School University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDivision of Infectious Diseases Department of Medicine Vanderbilt University Medical Center (VUMC)-
Descrição: dc.descriptionDepartment of Physiology and Pathology Federal University of Paraíba (UFPB), Paraíba-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Ribeirao Preto Medical School University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Ribeirao Preto Medical School University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 11/17611-7-
Descrição: dc.descriptionFAPESP: 12/23580-0-
Descrição: dc.descriptionFAPESP: 16/10964-5-
Descrição: dc.descriptionFAPESP: 17/04786-0-
Descrição: dc.descriptionFAPESP: 18/19638-9-
Descrição: dc.descriptionFAPESP: 2017/21629-5-
Descrição: dc.descriptionFAPESP: 2020/09327-6-
Descrição: dc.descriptionCNPq: 306363/2013-5-
Descrição: dc.descriptionCNPq: 307109/2016-0-
Descrição: dc.descriptionCNPq: 471945/2012-9-
Descrição: dc.descriptionCAPES: Finance Code 001-
Formato: dc.format321-330-
Idioma: dc.languageen-
Relação: dc.relationApoptosis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEfferocytosis-
Palavras-chave: dc.subjectInfected apoptotic cells-
Palavras-chave: dc.subjectLung inflammation-
Palavras-chave: dc.subjectMacrophages-
Título: dc.titleDifferent bacterial cargo in apoptotic cells drive distinct macrophage phenotypes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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