Insulin signaling and mitochondrial phenotype of skeletal muscle are programmed in utero by maternal diabetes

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.contributorInstitute of Physiology (IPHYS) of the Czech Academy of Sciences (CAS)-
Autor(es): dc.creatorKlöppel, Eduardo-
Autor(es): dc.creatorCruz, Larissa L.-
Autor(es): dc.creatorPrado-Souza, Laura F.L.-
Autor(es): dc.creatorEckhardt, Adam-
Autor(es): dc.creatorCorrente, José E.-
Autor(es): dc.creatordos Santos, Daniela C.-
Autor(es): dc.creatorJustulin, Luís A.-
Autor(es): dc.creatorRodrigues, Tiago-
Autor(es): dc.creatorVolpato, Gustavo T.-
Autor(es): dc.creatorDamasceno, Débora C.-
Data de aceite: dc.date.accessioned2025-08-21T17:20:48Z-
Data de disponibilização: dc.date.available2025-08-21T17:20:48Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2024.112199-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304611-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304611-
Descrição: dc.descriptionMaternal diabetes may influence glucose metabolism in adult offspring, an area with limited research on underlying mechanisms. Our study explored the impact of maternal hyperglycemia during pregnancy on insulin resistance development. Adult female Sprague-Dawley rats from control and diabetic mothers were mated, and their female offspring were monitored for 150 days. The rats were euthanized for blood and muscle samples. Maternal diabetes led to heightened insulin levels, increased HOMA-IR, elevated triglycerides, and a raised TyG index in adult offspring. Muscle samples showed a decreased protein expression of AMPK, PI3K, MAPK, DRP1, and MFF. These changes induced intergenerational metabolic programming in female pups, resulting in insulin resistance, dyslipidemia, and glucose intolerance by day 150. Findings highlight the offspring's adaptation to maternal hyperglycemia, involving insulin resistance, metabolic alterations, the downregulation of insulin signaling sensors, and disturbed mitochondrial morphology. Maintaining maternal glycemic control emerges as crucial in mitigating diabetes-associated disorders in adult offspring.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Gynecology and Obtetrics Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT), Mato Grosso State-
Descrição: dc.descriptionCenter for Natural and Human Sciences (CCNH) Federal University of ABC (UFABC), São Paulo State-
Descrição: dc.descriptionLaboratory of Translational Metabolism Institute of Physiology (IPHYS) of the Czech Academy of Sciences (CAS)-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Gynecology and Obtetrics Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionFAPESP: 2016/25207-5-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFetal programming-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectInsulin resistance-
Palavras-chave: dc.subjectMitochondria-
Palavras-chave: dc.subjectRat-
Palavras-chave: dc.subjectSkeletal muscle-
Título: dc.titleInsulin signaling and mitochondrial phenotype of skeletal muscle are programmed in utero by maternal diabetes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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