Delayed repair of the facial nerve and its negative impacts on nerve and muscle regeneration

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity Center of Adamantina (UNIFAI)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of West Paulista (UNOESTE)-
Autor(es): dc.contributorFaculty of the Midwest Paulista (FACOP)-
Autor(es): dc.creatorRodrigo de Souza Bueno, Cleuber-
Autor(es): dc.creatorVieira Buchaim, Daniela-
Autor(es): dc.creatorBarraviera, Benedito-
Autor(es): dc.creatorSeabra Ferreira, Rui-
Autor(es): dc.creatorSérgio da Silva Santos, Paulo-
Autor(es): dc.creatorHenrique Bertoni Reis, Carlos-
Autor(es): dc.creatorAugusto Cini, Marcelo-
Autor(es): dc.creatorCarlos Kuga, Milton-
Autor(es): dc.creatorMarco Rosa Junior, Geraldo-
Autor(es): dc.creatorLeone Buchaim, Rogerio-
Data de aceite: dc.date.accessioned2025-08-21T15:53:58Z-
Data de disponibilização: dc.date.available2025-08-21T15:53:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2023-0093-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304597-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304597-
Descrição: dc.descriptionBackground: In this experimental protocol, we evaluated the immediate and delayed repair of the buccal branch of the facial nerve (BBFN) with heterologous fibrin biopolymer (HFB) as a coaptation medium and the use of photobiomodulation (PBM), performing functional and histomorphometric analysis of the BBFN and perioral muscles. Methods: Twenty-eight rats were divided into eight groups using the BBFN bilaterally (the left nerve was used for PBM), namely: G1 – control group, right BBFN (without injury); G2 – control group, left BBFN (without injury + PBM); G3 – Denervated right BBFN (neurotmesis); G4 – Denervated left BBFN (neurotmesis + PBM); G5 – Immediate repair of right BBFN (neurotmesis + HFB); G6 – Immediate repair of left BBFN (neurotmesis + HFB + PBM); G7 – Delayed repair of right BBFN (neurotmesis + HFB); G8 – Delayed repair of left BBFN (neurotmesis + HFB + PBM). Delayed repair occurred after two weeks of denervation. All animals were sacrificed after six weeks postoperatively. Results: In the parameters of the BBFN, we observed inferior results in the groups with delayed repair, in relation to the groups with immediate repair, with a significant difference (p < 0.05) in the diameter of the nerve fiber, the axon, and the thickness of the myelin sheath of the group with immediate repair with PBM compared to the other experimental groups. In measuring the muscle fiber area, groups G7 (826.4 ± 69.90) and G8 (836.7 ± 96.44) were similar to G5 (882.8 ± 70.51). In the functional analysis, the G7 (4.10 ± 0.07) and G8 (4.12 ± 0.08) groups presented normal parameters. Conclusion: We demonstrated that delayed repair of BBFN is possible with HFB, but with worse results compared to immediate repair, and that PBM has a positive influence on nerve regeneration results in immediate repair.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry (FOB) University of São Paulo (USP), SP-
Descrição: dc.descriptionDentistry School University Center of Adamantina (UNIFAI), SP-
Descrição: dc.descriptionMedical School University Center of Adamantina (UNIFAI), SP-
Descrição: dc.descriptionGraduate Program in Structural and Functional Interactions in Rehabilitation University of Marilia (UNIMAR), SP-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science (FMVZ) University of São Paulo (USP), SP-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry (FOB) University of São Paulo (USP), SP-
Descrição: dc.descriptionUNIMAR Beneficent Hospital (HBU) University of Marilia (UNIMAR), SP-
Descrição: dc.descriptionMedical School University of West Paulista (UNOESTE), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDentistry School Faculty of the Midwest Paulista (FACOP), SP-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: 2021/11936-3-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiopolymers-
Palavras-chave: dc.subjectFacial nerve-
Palavras-chave: dc.subjectFibrin sealant-
Palavras-chave: dc.subjectNerve regeneration-
Palavras-chave: dc.subjectPhotobiomodulation-
Título: dc.titleDelayed repair of the facial nerve and its negative impacts on nerve and muscle regeneration-
Tipo de arquivo: dc.typelivro digital-
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