Impact of maternal protein restriction on the proteomic landscape of male rat lungs across the lifespan

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFox Chase Cancer Center-
Autor(es): dc.contributorSalvador Zubirán National Institute of Medical Sciences and Nutrition-
Autor(es): dc.contributorUniversidad Nacional Autónoma de México-
Autor(es): dc.creatorNaia Fioretto, Matheus-
Autor(es): dc.creatorMaciel, Flávia Alessandra-
Autor(es): dc.creatorBarata, Luísa Annibal-
Autor(es): dc.creatorRibeiro, Isabelle Tenori-
Autor(es): dc.creatorBasso, Carolina Beatriz Pinheiro-
Autor(es): dc.creatorFerreira, Marcel Rodrigues-
Autor(es): dc.creatordos Santos, Sérgio Alexandre Alcantara-
Autor(es): dc.creatorMattos, Renato-
Autor(es): dc.creatorBaptista, Hecttor Sebastian-
Autor(es): dc.creatorPortela, Luiz Marcos Frediane-
Autor(es): dc.creatorPadilha, Pedro Magalhães-
Autor(es): dc.creatorFelisbino, Sérgio Luis-
Autor(es): dc.creatorScarano, Wellerson Rodrigo-
Autor(es): dc.creatorZambrano, Elena-
Autor(es): dc.creatorJustulin, Luis Antonio-
Data de aceite: dc.date.accessioned2025-08-21T18:34:12Z-
Data de disponibilização: dc.date.available2025-08-21T18:34:12Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2024.112348-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304592-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304592-
Descrição: dc.descriptionThe developmental origins of healthy and disease (DOHaD) concept has demonstrated a higher rate of chronic diseases in the adult population of individuals whose mothers experienced severe maternal protein restriction (MPR). Using proteomic and in silico analyses, we investigated the lung proteomic profile of young and aged rats exposed to MPR during pregnancy and lactation. Our results demonstrated that MPR lead to structural and immune system pathways changes, and this outcome is coupled with a rise in the PI3k-AKT-mTOR signaling pathway, with increased MMP-2 activity, and CD8 expression in the early life, with long-term effects with aging. This led to the identification of commonly or inversely differentially expressed targets in early life and aging, revealing dysregulated pathways related to the immune system, stress, muscle contraction, tight junctions, and hemostasis. We identified three miRNAs (miR-378a-3p, miR-378a-5p, let-7a-5p) that regulate four proteins (ACTN4, PPIA, HSPA5, CALM1) as probable epigenetic lung marks generated by MPR. In conclusion, MPR impacts the lungs early in life, increasing the possibility of long-lasting negative outcomes for respiratory disorders in the offspring.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit - Unipex School of Medicine São Paulo State University - Unesp, São Paulo-
Descrição: dc.descriptionCancer Signaling and Epigenetics Program Fox Chase Cancer Center-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment Reproductive Biology Salvador Zubirán National Institute of Medical Sciences and Nutrition-
Descrição: dc.descriptionFacultad de Química Universidad Nacional Autónoma de México-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit - Unipex School of Medicine São Paulo State University - Unesp, São Paulo-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionFAPESP: 2017/01063-7-
Descrição: dc.descriptionFAPESP: 2022/03990-0-
Descrição: dc.descriptionCNPq: 310663/2018-0-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectEarly life-
Palavras-chave: dc.subjectLungs-
Palavras-chave: dc.subjectMaternal malnutrition-
Palavras-chave: dc.subjectProteomics-
Título: dc.titleImpact of maternal protein restriction on the proteomic landscape of male rat lungs across the lifespan-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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