Breaking barriers: The potential of nanosystems in antituberculosis therapy

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Autor(es): dc.contributorSanta Maria Catholic University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Groningen-
Autor(es): dc.contributorUniversity of Helsinki-
Autor(es): dc.creatorCarnero Canales, Christian S.-
Autor(es): dc.creatorMarquez Cazorla, Jessica Ingrid-
Autor(es): dc.creatorMarquez Cazorla, Renzo Marianito-
Autor(es): dc.creatorRoque-Borda, Cesar Augusto-
Autor(es): dc.creatorPolinário, Giulia-
Autor(es): dc.creatorFigueroa Banda, Rufo A.-
Autor(es): dc.creatorSábio, Rafael Miguel-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorSantos, Hélder A.-
Autor(es): dc.creatorPavan, Fernando Rogério-
Data de aceite: dc.date.accessioned2025-08-21T15:21:27Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:27Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bioactmat.2024.05.013-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304552-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304552-
Descrição: dc.descriptionTuberculosis (TB), caused by Mycobacterium tuberculosis, continues to pose a significant threat to global health. The resilience of TB is amplified by a myriad of physical, biological, and biopharmaceutical barriers that challenge conventional therapeutic approaches. This review navigates the intricate landscape of TB treatment, from the stealth of latent infections and the strength of granuloma formations to the daunting specters of drug resistance and altered gene expression. Amidst these challenges, traditional therapies often fail, contending with inconsistent bioavailability, prolonged treatment regimens, and socioeconomic burdens. Nanoscale Drug Delivery Systems (NDDSs) emerge as a promising beacon, ready to overcome these barriers, offering better drug targeting and improved patient adherence. Through a critical approach, we evaluate a spectrum of nanosystems and their efficacy against MTB both in vitro and in vivo. This review advocates for the intensification of research in NDDSs, heralding their potential to reshape the contours of global TB treatment strategies.-
Descrição: dc.descriptionUniversitair Medisch Centrum Groningen-
Descrição: dc.descriptionSchool of Pharmacy Biochemistry and Biotechnology Santa Maria Catholic University-
Descrição: dc.descriptionTuberculosis Research Laboratory School of Pharmaceutical Science Sao Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Medicine Santa Maria Catholic University-
Descrição: dc.descriptionSchool of Pharmaceutical Science Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biomaterials and Biomedical Technology University Medical Center Groningen (UMCG) University of Groningen-
Descrição: dc.descriptionDrug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki-
Descrição: dc.descriptionTuberculosis Research Laboratory School of Pharmaceutical Science Sao Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science Sao Paulo State University (UNESP)-
Formato: dc.format106-134-
Idioma: dc.languageen-
Relação: dc.relationBioactive Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBarriers-
Palavras-chave: dc.subjectDrug resistance-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectNanoscale drug delivery systems-
Palavras-chave: dc.subjectTuberculosis-
Título: dc.titleBreaking barriers: The potential of nanosystems in antituberculosis therapy-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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