Role of corticotropin-releasing factor neurotransmission in the lateral hypothalamus on baroreflex impairment evoked by chronic variable stress in rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBarretto-de-Souza, Lucas-
Autor(es): dc.creatorBenini, Ricardo-
Autor(es): dc.creatorReis-Silva, Lilian L.-
Autor(es): dc.creatorBusnardo, Cristiane-
Autor(es): dc.creatorCrestani, Carlos C.-
Data de aceite: dc.date.accessioned2025-08-21T19:46:35Z-
Data de disponibilização: dc.date.available2025-08-21T19:46:35Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00424-024-02904-5-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304535-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304535-
Descrição: dc.descriptionDespite the importance of physiological responses to stress in a short-term, chronically these adjustments may be harmful and lead to diseases, including cardiovascular diseases. The lateral hypothalamus (LH) has been reported to be involved in expression of physiological and behavioral responses to stress, but the local neurochemical mechanisms involved are not completely described. The corticotropin-releasing factor (CRF) neurotransmission is a prominent brain neurochemical system implicated in the physiological and behavioral changes induced by aversive threats. Furthermore, chronic exposure to aversive situations affects the CRF neurotransmission in brain regions involved in stress responses. Therefore, in this study, we evaluated the influence of CRF neurotransmission in the LH on changes in cardiovascular function and baroreflex activity induced by chronic variable stress (CVS). We identified that CVS enhanced baseline arterial pressure and impaired baroreflex function, which were followed by increased expression of CRF2, but not CRF1, receptor expression within the LH. Local microinjection of either CRF1 or CRF2 receptor antagonist within the LH inhibited the baroreflex impairment caused by CVS, but without affecting the mild hypertension. Taken together, the findings documented in this study suggest that LH CRF neurotransmission participates in the baroreflex impairment related to chronic stress exposure.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Pharmacology Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01, São Paulo-
Descrição: dc.descriptionLaboratory of Pharmacology Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01, São Paulo-
Descrição: dc.descriptionFAPESP: 2017/19249-0-
Descrição: dc.descriptionFAPESP: 2019/24478-3-
Descrição: dc.descriptionCNPq: 304484/2022-9-
Descrição: dc.descriptionCNPq: 431339/2018-0-
Descrição: dc.descriptionCAPES: Finance Code 001-
Formato: dc.format351-364-
Idioma: dc.languageen-
Relação: dc.relationPflugers Archiv European Journal of Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutonomic activity-
Palavras-chave: dc.subjectCardiovascular-
Palavras-chave: dc.subjectCRF-
Palavras-chave: dc.subjectEmotion-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectHypothalamus-
Título: dc.titleRole of corticotropin-releasing factor neurotransmission in the lateral hypothalamus on baroreflex impairment evoked by chronic variable stress in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.