Causes and prognosis of adults experiencing a first seizure in adulthood: A pilot cohort study conducted in five countries in Latin America

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Cuenca-
Autor(es): dc.contributorHospital Santa Inés-
Autor(es): dc.contributorUniversidad de Azuay-
Autor(es): dc.contributorMinisterio de Salud Pública-
Autor(es): dc.contributorUniversidad San Francisco de Quito-
Autor(es): dc.contributorUniversidad Nacional Autónoma de México-
Autor(es): dc.contributorInstituto Nacional de Neurología y Neurocirugia de-
Autor(es): dc.contributorHospital Interzonal General de Agudos Prof. Dr. Rodolfo Rossi de La Plata-
Autor(es): dc.contributorCONICET-
Autor(es): dc.contributorHospital Clínico de la Universidad de Chile-
Autor(es): dc.contributorHospital 20 de Noviembre-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital “José Carrasco” Instituto Ecuatoriano de Seguridad Social de Cuenca-
Autor(es): dc.contributorCity University of New York-
Autor(es): dc.contributorEpidemiology & Prevention Donald and Barbara Zucker School of Medicine at Hofstra University/Northwell Health-
Autor(es): dc.creatorCarpio, Arturo-
Autor(es): dc.creatorSalgado, Carla-
Autor(es): dc.creatorDiCapua, Daniela-
Autor(es): dc.creatorFleury, Agnes-
Autor(es): dc.creatorSuastegui, Roberto-
Autor(es): dc.creatorGiagante, Brenda-
Autor(es): dc.creatorAguilera, Ledda-
Autor(es): dc.creatorQuijada, Alonso-
Autor(es): dc.creatorNuñez, Lilia-
Autor(es): dc.creatorVillanueva, Manuela-
Autor(es): dc.creatorPlascencia-Alvarez, Noel-
Autor(es): dc.creatorHamamoto Filho, Pedro T-
Autor(es): dc.creatorPiedra, Luis M.-
Autor(es): dc.creatorSilva-Rosas, Carlos-
Autor(es): dc.creatorKelvin, Elizabeth A.-
Data de aceite: dc.date.accessioned2025-08-21T17:27:19Z-
Data de disponibilização: dc.date.available2025-08-21T17:27:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/epi4.12900-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304524-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304524-
Descrição: dc.descriptionThere are limited data on first seizure (FS) among adults in low and middle-income countries. We describe findings from a prospective cohort study involving 180 adults presenting with seizures in emergency departments in five Latin American countries. Overall, 102 participants (56.7%) had acute symptomatic seizures (ASyS) while 78 (43.3%) had unprovoked seizures (UPS). Among patients with ASyS, 55 (53.9%) had structural causes, with stroke (n = 24, 23.5%), tumor (n = 10, 9.8%), and trauma (n = 3, 3%) being the most frequent. Nineteen patients (18.6%) had infectious causes, including four (4%) with meningoencephalitis, three (3%) neurocysticercosis, and two (2%) bacterial meningoencephalitis. Twenty patients (19.6%) had metabolic/toxic evidence, including four (4%) with uremic encephalopathy, two (2%) hyponatremia, and three (3%) acute alcohol intoxication. Immune dysfunction was present in seven (7%) patients and neurodegenerative in two (2%). Among participants with UPS, 45 (57.7%) had unknown etiology, 24 (30.7%) had evidence of structural disorders (remote symptomatic), four (5%) were related to infectious etiology (>7 days before the seizure), and five (6.4%) had genetic causes. During the 3- and 6-month follow-up, 29.8% and 14% of patients with UPS, respectively, experienced seizure recurrence, while 23.9% and 24.5% of patients with ASyS had seizure recurrence. Longer follow-up is necessary to assess seizure recurrence for patients with ASyS after the acute cause is resolved and to determine the 10-year risk of recurrence, which is part of the definition of epilepsy. Plain Language Summary: We monitored 180 adults who presented with their first seizure in emergency departments across five Latin American countries. Among these patients, 57% had acute symptomatic seizures, with structural causes such as stroke (23%), infection (17%), or tumor (10%) being more prevalent. Among the 43% with unprovoked seizures, 58% showed no identifiable acute cause, while 6.4% were due to genetics. Within 3 months after their initial seizure, 26.6% of individuals experienced a second seizure, with 11.9% continuing to have seizures in Months 3–6. Between Months 3 and 6, an additional 20% of patients encountered a second seizure. Research is needed to better understand the cause and prognosis of these patients to improve outcomes.-
Descrição: dc.descriptionSchool of Medicine University of Cuenca-
Descrição: dc.descriptionHospital Santa Inés-
Descrição: dc.descriptionFacultad de Medicina Universidad de Azuay-
Descrição: dc.descriptionHospital Eugenio Espejo Ministerio de Salud Pública-
Descrição: dc.descriptionUniversidad San Francisco de Quito-
Descrição: dc.descriptionDepartamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigación Biomédicas Universidad Nacional Autónoma de México-
Descrição: dc.descriptionInstituto Nacional de Neurología y Neurocirugia de-
Descrição: dc.descriptionHospital Interzonal General de Agudos Prof. Dr. Rodolfo Rossi de La Plata-
Descrição: dc.descriptionHospital de Alta Complejidad El Cruce “Néstor Kirchner” ENyS CONICET-
Descrição: dc.descriptionHospital Clínico de la Universidad de Chile-
Descrição: dc.descriptionHospital 20 de Noviembre-
Descrição: dc.descriptionBotucatu Medical School UNESP – São Paulo State University-
Descrição: dc.descriptionHospital “José Carrasco” Instituto Ecuatoriano de Seguridad Social de Cuenca-
Descrição: dc.descriptionDepartment of Epidemiology & Biostatistics CUNY Graduate School of Public Health and Health Policy City University of New York-
Descrição: dc.descriptionCUNY Institute for Implementation Science in Population Health City University of New York-
Descrição: dc.descriptionDepartment of Occupational Health Epidemiology & Prevention Donald and Barbara Zucker School of Medicine at Hofstra University/Northwell Health-
Descrição: dc.descriptionBotucatu Medical School UNESP – São Paulo State University-
Formato: dc.format776-784-
Idioma: dc.languageen-
Relação: dc.relationEpilepsia Open-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectacute symptomatic seizures-
Palavras-chave: dc.subjectepilepsy-
Palavras-chave: dc.subjectetiology-
Palavras-chave: dc.subjectfirst seizure-
Palavras-chave: dc.subjectneurocysticercosis-
Título: dc.titleCauses and prognosis of adults experiencing a first seizure in adulthood: A pilot cohort study conducted in five countries in Latin America-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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