Green tea and hyaluronic acid gel enhance fibroblast activation and improves the gingival healing post-third molar extraction

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentro Universitário Do Triângulo-
Autor(es): dc.creatorBonatto, Mariana da Silva-
Autor(es): dc.creatorFeltran, Geórgia da Silva-
Autor(es): dc.creatorBarbosa, Thamires Prazeres-
Autor(es): dc.creatorPereira, Davisson Alves-
Autor(es): dc.creatorSantos, Samara de Souza-
Autor(es): dc.creatorMendes, Pedro Gomes Junqueira-
Autor(es): dc.creatore Pessoa, Roberto Sales-
Autor(es): dc.creatorBezerra, Fábio José Barbosa-
Autor(es): dc.creatorZambuzzi, Willian Fernando-
Autor(es): dc.creatorde Oliveira, Guilherme José Pimentel Lopes-
Data de aceite: dc.date.accessioned2025-08-21T20:31:31Z-
Data de disponibilização: dc.date.available2025-08-21T20:31:31Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-024-57821-5-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304500-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304500-
Descrição: dc.descriptionThis study evaluates the effects of a green tea (Camellia sinensis) and hyaluronic acid gel on fibroblast activity and alveolar bone repair following third molar extractions. By examining the gene expression related to cell survival, proliferation, and angiogenesis, the study bridges in vitro findings with clinical outcomes in a split-mouth randomized trial. Human fibroblasts were exposed to the treatment gel, analysing gene expression through RT-qPCR. Twenty participants undergoing bilateral third molar extractions received the test gel on one side and a placebo on the other. Assessments included patient-reported outcomes, professional evaluations, and radiographic analyses at multiple postoperative intervals. The test gel significantly enhanced AKT, CDKs, and VEGF gene expressions, indicating a positive effect on angiogenesis and cell proliferation. Clinically, it resulted in reduced exudate, swelling, and secondary interventions, with radiographs showing improved alveolar bone density after 90 days. The green tea and hyaluronic acid gel significantly improves soft tissue and bone healing post-extraction, offering a promising adjunctive therapy for enhancing postoperative recovery. This gel represents a novel adjuvant treatment option for facilitating improved healing outcomes after third molar extractions, highlighting its potential utility in clinical dental practice.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSchool of Dentistry - Universidade Federal de Uberlândia (UFU), Pará, Av., 1760-1844, MG-
Descrição: dc.descriptionUNESP - Instituto de Biociências São Paulo State University, Campus de Botucatu, Rua Prof a. Dr a. Irina Delanova Gemtchujnicov, s/nº, SP-
Descrição: dc.descriptionCentro Universitário Do Triângulo, MG-
Descrição: dc.descriptionUNESP - Instituto de Biociências São Paulo State University, Campus de Botucatu, Rua Prof a. Dr a. Irina Delanova Gemtchujnicov, s/nº, SP-
Descrição: dc.descriptionCNPq: Grants CNPq – Financial code 001-
Descrição: dc.descriptionCNPq: Grants INCT Saúde Oral e Odontologia 406840/2022-9-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectFibroblasts-
Palavras-chave: dc.subjectGreen tea-
Palavras-chave: dc.subjectHyaluronic acid-
Palavras-chave: dc.subjectOral Surgery-
Palavras-chave: dc.subjectTissue regeneration-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleGreen tea and hyaluronic acid gel enhance fibroblast activation and improves the gingival healing post-third molar extraction-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.