Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorLong School of Medicine-
Autor(es): dc.contributorSchool of Osteopathic Medicine-
Autor(es): dc.contributorConsejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)-
Autor(es): dc.contributorInstituto Mexicano del Seguro Social-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIndependent Researcher-
Autor(es): dc.contributorUniversity of Urbino Carlo Bo-
Autor(es): dc.contributorChulabhorn Royal Academy-
Autor(es): dc.creatorReiter, Russel J.-
Autor(es): dc.creatorSharma, Ramaswamy N.-
Autor(es): dc.creatorManucha, Walter-
Autor(es): dc.creatorRosales-Corral, Sergio-
Autor(es): dc.creatorAlmieda Chuffa, Luiz Gustavo de-
Autor(es): dc.creatorLoh, Doris-
Autor(es): dc.creatorLuchetti, Francesca-
Autor(es): dc.creatorBalduini, Walter-
Autor(es): dc.creatorGovitrapong, Piyarat-
Data de aceite: dc.date.accessioned2025-08-21T16:48:49Z-
Data de disponibilização: dc.date.available2025-08-21T16:48:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.arr.2024.102480-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304491-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304491-
Descrição: dc.descriptionMitochondria functionally degrade as neurons age. Degenerative changes cause inefficient oxidative phosphorylation (OXPHOS) and elevated electron leakage from the electron transport chain (ETC) promoting increased intramitochondrial generation of damaging reactive oxygen and reactive nitrogen species (ROS and RNS). The associated progressive accumulation of molecular damage causes an increasingly rapid decline in mitochondrial physiology contributing to aging. Melatonin, a multifunctional free radical scavenger and indirect antioxidant, is synthesized in the mitochondrial matrix of neurons. Melatonin reduces electron leakage from the ETC and elevates ATP production; it also detoxifies ROS/RNS and via the SIRT3/FOXO pathway it upregulates activities of superoxide dismutase 2 and glutathione peroxidase. Melatonin also influences glucose processing by neurons. In neurogenerative diseases, neurons often adopt Warburg-type metabolism which excludes pyruvate from the mitochondria causing reduced intramitochondrial acetyl coenzyme A production. Acetyl coenzyme A supports the citric acid cycle and OXPHOS. Additionally, acetyl coenzyme A is a required co-substrate for arylalkylamine-N-acetyl transferase, which rate limits melatonin synthesis; therefore, melatonin production is diminished in cells that experience Warburg-type metabolism making mitochondria more vulnerable to oxidative stress. Moreover, endogenously produced melatonin diminishes during aging, further increasing oxidative damage to mitochondrial components. More normal mitochondrial physiology is preserved in aging neurons with melatonin supplementation.-
Descrição: dc.descriptionDepartment of Cell Systems and Anatomy UT Health San Antonio Long School of Medicine-
Descrição: dc.descriptionApplied Biomedical Sciences University of the Incarnate Word School of Osteopathic Medicine-
Descrição: dc.descriptionInstituto de Medicina y Biologia Experimental de Cuyo (IMBECU) Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)-
Descrição: dc.descriptionCentro de Investigacion Biomedica de Occidente Instituto Mexicano del Seguro Social-
Descrição: dc.descriptionDepartamento de Biologia Estrutural e Funcional Setor de Anatomia - Instituto de Biociências IBB/UNESP Campus Botucatu, São Paulo-
Descrição: dc.descriptionIndependent Researcher-
Descrição: dc.descriptionDepartment of Biomolecular Sciences University of Urbino Carlo Bo-
Descrição: dc.descriptionChulabhorn Graduate Institute Chulabhorn Royal Academy, Laksi-
Descrição: dc.descriptionDepartamento de Biologia Estrutural e Funcional Setor de Anatomia - Instituto de Biociências IBB/UNESP Campus Botucatu, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationAgeing Research Reviews-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcetyl coenzyme A-
Palavras-chave: dc.subjectAlzheimer disease-
Palavras-chave: dc.subjectAmyotrophic lateral sclerosis-
Palavras-chave: dc.subjectAntioxidative enzymes-
Palavras-chave: dc.subjectHuntington disease-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectParkinson disease-
Palavras-chave: dc.subjectRadical scavenging-
Palavras-chave: dc.subjectWarburg metabolism-
Título: dc.titleDysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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