Kappa-opioid receptor blockade in the inferior colliculus of prey threatened by pit vipers decreases anxiety and panic-like behaviour

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorLaboratory of Neuronal Plasticity-
Autor(es): dc.contributorBoehringer Ingelheim Pharmaceuticals Gesellschaft mit Beschränkter Haftung & Compagnie Kommanditgesellschaft-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Rio Grande do Norte (UFRN)-
Autor(es): dc.contributorBehavioural Neurosciences Institute (INeC)-
Autor(es): dc.contributorAlfenas Federal University (ICB-UNIFAL)-
Autor(es): dc.creatorCalvo, Fabrício-
Autor(es): dc.creatorDos Anjos-Garcia, Tayllon-
Autor(es): dc.creatorPaschoalin-Maurin, Tatiana-
Autor(es): dc.creatorBazaglia-De-Sousa, Guilherme-
Autor(es): dc.creatorDe Paula Rodrigues, Bruno Mangili-
Autor(es): dc.creatorLobão-Soares, Bruno-
Autor(es): dc.creatorAlmada, Rafael Carvalho-
Autor(es): dc.creatorWotjak, Carsten T.-
Autor(es): dc.creatorCoimbra, Norberto Cysne-
Data de aceite: dc.date.accessioned2025-08-21T17:32:34Z-
Data de disponibilização: dc.date.available2025-08-21T17:32:34Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/neu.2024.30-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304478-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304478-
Descrição: dc.descriptionThe dorsal midbrain comprises dorsal columns of the periaqueductal grey matter and corpora quadrigemina. These structures are rich in beta-endorphinergic and leu-enkephalinergic neurons and receive GABAergic inputs from substantia nigra pars reticulata. Although the inferior colliculus (IC) is mainly involved in the acoustic pathways, the electrical and chemical stimulation of central and pericentral nuclei of the IC elicits a vigorous defensive behaviour. The defensive immobility and escape elicited by IC activation is commonly related to panic-like emotional states. To investigate the role of κ-opioid receptor of the IC in the antiaversive effects of endogenous opioid receptor blockade in a dangerous situation, male Wistar rats were pretreated in the IC with the κ-opioid receptor-selective antagonist nor-binaltorphimine at different concentrations and submitted to the non-enriched polygonal arena for a snake panic test in the presence of a rattlesnake and, after 24 h, prey were resubmitted to the experimental context. The snakes elicited in prey a set of antipredatory behaviours, such as the anxiety-like responses of defensive attention and risk assessment, and the panic-like reactions of defensive immobility and either escape or active avoidance during the elaboration of unconditioned and conditioned fear-related responses. Pretreatment of the IC with microinjections of nor-binaltorphimine at higher concentrations significantly decreased the frequency and duration of both anxiety- and panic-attack-like behaviours. These findings suggest that κ-opioid receptor blockade in the IC causes anxiolytic- and panicolytic-like responses in threatening conditions, and that kappa-opioid receptor-selective antagonists can be a putative coadjutant treatment for panic syndrome treatment.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Neuroanatomy & Neuropsychobiology Department of Pharmacology School of Medicine of Ribeirão Preto The University of São Paulo (FMRP-USP), São Paulo-
Descrição: dc.descriptionMax Planck Institute of Psychiatry Department of Stress Neurobiology and Neurogenetics Laboratory of Neuronal Plasticity-
Descrição: dc.descriptionCentral Nervous System Diseases Research Boehringer Ingelheim Pharmaceuticals Gesellschaft mit Beschränkter Haftung & Compagnie Kommanditgesellschaft, an der Riβ-
Descrição: dc.descriptionLaboratory of Neurobiology and Neurobiotechnology Department of Biological Sciences School of Science Humanities and Languages São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Federal University of Rio Grande do Norte (UFRN), RN-
Descrição: dc.descriptionBehavioural Neurosciences Institute (INeC), São Paulo-
Descrição: dc.descriptionNAP-USP-Neurobiology of Emotions Research Centre (NuPNE) Ribeirão Preto School of Medicine The University of São Paulo (FMRP-USP), Ribeirão Preto-
Descrição: dc.descriptionOphidiarium LNN-FMRP-USP/INeC Ribeirão Preto School of Medicine The University of São Paulo (FMRP-USP), São Paulo-
Descrição: dc.descriptionDepartment Physiological Sciences Institute for Biomedical Sciences Alfenas Federal University (ICB-UNIFAL), Minas Gerais-
Descrição: dc.descriptionLaboratory of Neurobiology and Neurobiotechnology Department of Biological Sciences School of Science Humanities and Languages São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2007/01174-1-
Descrição: dc.descriptionFAPESP: 2012/03798-0-
Descrição: dc.descriptionFAPESP: 2017/11855-8-
Formato: dc.format457-469-
Idioma: dc.languageen-
Relação: dc.relationActa Neuropsychiatrica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectconditioned fear-
Palavras-chave: dc.subjectCrotalus durissus terrificus-
Palavras-chave: dc.subjectendogenous opioid system-
Palavras-chave: dc.subjectinferior colliculus-
Palavras-chave: dc.subjectinnate fear-
Palavras-chave: dc.subjectpanic attacks-
Palavras-chave: dc.subjectprey versus rattlesnake paradigm-
Título: dc.titleKappa-opioid receptor blockade in the inferior colliculus of prey threatened by pit vipers decreases anxiety and panic-like behaviour-
Tipo de arquivo: dc.typelivro digital-
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