Resveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells

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Autor(es): dc.contributorFederal University of Rio Grande do Norte (UFRN)-
Autor(es): dc.contributorOswaldo Cruz Foundation (FIOCRUZ)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorFederal University of Amazonas-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDourado, Douglas-
Autor(es): dc.creatorBatista, Fabiana Pacheco Reis-
Autor(es): dc.creatorPhiladelpho, Biane Oliveira-
Autor(es): dc.creatorde Souza, Myla Lôbo-
Autor(es): dc.creatorde Cerqueira e Silva, Mariana Barros-
Autor(es): dc.creatorde Grandis, Rone Aparecido-
Autor(es): dc.creatorMiranda, Priscila Anjos-
Autor(es): dc.creatorColauto, Nelson Barros-
Autor(es): dc.creatorPereira, Daniel T.-
Autor(es): dc.creatorFormiga, Fabio Rocha-
Autor(es): dc.creatorCilli, Eduardo Maffud-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorOliveira de Souza, Carolina-
Autor(es): dc.creatorFerreira, Ederlan de Souza-
Data de aceite: dc.date.accessioned2025-08-21T20:51:10Z-
Data de disponibilização: dc.date.available2025-08-21T20:51:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms241512112-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304439-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304439-
Descrição: dc.descriptionThis study aimed to evaluate Attalea funifera seed oil with or without resveratrol entrapped in organogel nanoparticles in vitro against A375 human melanoma tumor cells. Organogel nanoparticles with seed oil (SON) or with resveratrol entrapped in the seed oil (RSON) formed functional organogel nanoparticles that showed a particle size <100 nm, polydispersity index <0.3, negative zeta potential, and maintenance of electrical conductivity. The resveratrol entrapment efficiency in RSON was 99 ± 1%. The seed oil and SON showed no cytotoxicity against human non-tumor cells or tumor cells. Resveratrol at 50 μg/mL was cytotoxic for non-tumor cells, and was cytotoxic for tumor cells at 25 μg/mL. Resveratrol entrapped in RSON showed a decrease in cytotoxicity against non-tumor cells and cytotoxic against tumor cells at 50 μg/mL. Thus, SON is a potential new platform for the delivery of resveratrol with selective cytotoxic activity in the treatment of melanoma.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCollege of Environmental Science and Forestry, State University of New York-
Descrição: dc.descriptionEdema-Steernberg Foundation-
Descrição: dc.descriptionEsperantic Studies Foundation-
Descrição: dc.descriptionEuropean Science Foundation-
Descrição: dc.descriptionEuropean Social Fund-
Descrição: dc.descriptionSchool of Pharmacy Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Faria Street, RN-
Descrição: dc.descriptionDepartment of Immunology Aggeu Magalhães Institute (IAM) Oswaldo Cruz Foundation (FIOCRUZ), PE-
Descrição: dc.descriptionSchool of Pharmacy Federal University of Bahia, Barão de Jeremoabo Street, BA-
Descrição: dc.descriptionCollege of Pharmacy Federal University of Pernambuco, Professor Artur de Sá Street, PE-
Descrição: dc.descriptionSchool of Pharmacy Federal University of Amazonas, General Rodrigo Octávio Jordão Ramos Avenue, AM-
Descrição: dc.descriptionSchool of Pharmacy São Paulo State University (UNESP), Araraquara-Jaú Road, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Prof. Francisco Swgni Street, SP-
Descrição: dc.descriptionSchool of Pharmacy São Paulo State University (UNESP), Araraquara-Jaú Road, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Prof. Francisco Swgni Street, SP-
Descrição: dc.descriptionCNPq: 301975/2018-3-
Descrição: dc.descriptionCollege of Environmental Science and Forestry, State University of New York: 316355/2021-6-
Descrição: dc.descriptionEdema-Steernberg Foundation: 316355/2021-6-
Descrição: dc.descriptionEsperantic Studies Foundation: 316355/2021-6-
Descrição: dc.descriptionEuropean Science Foundation: 316355/2021-6-
Descrição: dc.descriptionEuropean Social Fund: 316355/2021-6-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcell viability-
Palavras-chave: dc.subjectgelled lipid nanoparticles-
Palavras-chave: dc.subjectmedium-chain fatty acids-
Palavras-chave: dc.subjectpiassava seed oil-
Palavras-chave: dc.subjectskin cancer-
Título: dc.titleResveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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