Framework for Research Gaps in Pediatric Ventilator Liberation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorDivision of Pediatric Critical Care-
Autor(es): dc.contributorUniversity of Southern California-
Autor(es): dc.contributorUniversity of Southern California Keck School of Medicine-
Autor(es): dc.contributorCiudad Autónoma de Buenos Aires-
Autor(es): dc.contributorEdge Hill University Health Research Institute-
Autor(es): dc.contributorImperial College London-
Autor(es): dc.contributorUniversity of Groningen-
Autor(es): dc.contributorBioBizkaia Health Research Institute-
Autor(es): dc.contributorUniversité de Montréal-
Autor(es): dc.contributorPostgraduate Institute of Medical Education and Research-
Autor(es): dc.contributorQueen's University Belfast-
Autor(es): dc.contributorIndiana University School of Medicine-
Autor(es): dc.contributorChildren's Hospital of Philadelphia-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorand Cincinnati Children's Hospital Medical Center Heart Institute-
Autor(es): dc.contributorUniversidad de la República-
Autor(es): dc.contributorSeattle Children's Hospital and University of Washington-
Autor(es): dc.contributorChildren's Hospital Los Angeles-
Autor(es): dc.contributorCopenhagen University Hospital-
Autor(es): dc.contributorKing's College London-
Autor(es): dc.contributorDuke University-
Autor(es): dc.contributorRady Children's Hospital-
Autor(es): dc.contributorKK Women's and Children's Hospital-
Autor(es): dc.contributorUniversity of Southern California and Keck School of Medicine-
Autor(es): dc.creatorAbu-Sultaneh, Samer-
Autor(es): dc.creatorIyer, Narayan Prabhu-
Autor(es): dc.creatorFernández, Analía-
Autor(es): dc.creatorTume, Lyvonne N.-
Autor(es): dc.creatorKneyber, Martin C.J.-
Autor(es): dc.creatorLópez-Fernández, Yolanda M.-
Autor(es): dc.creatorEmeriaud, Guillaume-
Autor(es): dc.creatorRamnarayan, Padmanabhan-
Autor(es): dc.creatorKhemani, Robinder G.-
Autor(es): dc.creatorBaranwal, Arun Kumar-
Autor(es): dc.creatorBlackwood, Bronagh-
Autor(es): dc.creatorCraven, Hannah J.-
Autor(es): dc.creatorCurley, Martha A.Q.-
Autor(es): dc.creatorEssouri, Sandrine-
Autor(es): dc.creatorFioretto, Jose Roberto-
Autor(es): dc.creatorGaies, Michael-
Autor(es): dc.creatorGonzález-Dambrauskas, Sebastián-
Autor(es): dc.creatorHartmann, Silvia M.M.-
Autor(es): dc.creatorHotz, Justin Christian-
Autor(es): dc.creatorJouvet, Philippe-
Autor(es): dc.creatorKorang, Steven Kwasi-
Autor(es): dc.creatorMastropietro, Christopher W.-
Autor(es): dc.creatorNapolitano, Natalie-
Autor(es): dc.creatorNewth, Christopher J.L.-
Autor(es): dc.creatorRafferty, Gerrard F.-
Autor(es): dc.creatorRose, Louise-
Autor(es): dc.creatorRotta, Alexandre T.-
Autor(es): dc.creatorWerho, David K.-
Autor(es): dc.creatorWhipple, Elizabeth C.-
Autor(es): dc.creatorMing Wong, Judith Ju-
Data de aceite: dc.date.accessioned2025-08-21T19:48:19Z-
Data de disponibilização: dc.date.available2025-08-21T19:48:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.chest.2024.05.012-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304417-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304417-
Descrição: dc.descriptionBackground: The 2023 International Pediatric Ventilator Liberation Clinical Practice Guidelines provided evidence-based recommendations to guide pediatric critical care providers on how to perform daily aspects of ventilator liberation. However, because of the lack of high-quality pediatric studies, most recommendations were conditional based on very low to low certainty of evidence. Research Question: What are the research gaps related to pediatric ventilator liberation that can be studied to strengthen the evidence for future updates of the guidelines? Study Design and Methods: We conducted systematic reviews of the literature in eight predefined Population, Intervention, Comparator, Outcome (PICO) areas related to pediatric ventilator liberation to generate recommendations. Subgroups responsible for each PICO question subsequently identified major research gaps by synthesizing the literature. These gaps were presented at an international symposium at the Pediatric Acute Lung Injury and Sepsis Investigators meeting in spring 2022 for open discussion. Feedback was incorporated, and final evaluation of research gaps are summarized herein. Although randomized controlled trials (RCTs) represent the highest level of evidence, the panel sought to highlight areas where alternative study designs also may be appropriate, given challenges with conducting large multicenter RCTs in children. Results: Significant research gaps were identified in six broad areas related to pediatric ventilator liberation. Several of these areas necessitate multicenter RCTs to provide definitive results, whereas other gaps can be addressed with multicenter observational studies or quality improvement initiatives. Furthermore, a need for some physiologic studies in several areas remains, particularly regarding newer diagnostic methods to improve identification of patients at high risk of extubation failure. Interpretation: Although pediatric ventilator liberation guidelines have been created, the certainty of evidence remains low and multiple research gaps exist that should be bridged through high-quality RCTs, multicenter observational studies, and quality improvement initiatives.-
Descrição: dc.descriptionNational Heart, Lung, and Blood Institute-
Descrição: dc.descriptionEunice Kennedy Shriver National Institute of Child Health and Human Development-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionDivision of Pediatric Critical Care Department of Pediatrics Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine Indianapolis-
Descrição: dc.descriptionFetal and Neonatal Institute Division of Neonatology Children's Hospital Los Angeles Department of Pediatrics Keck School of Medicine University of Southern California-
Descrição: dc.descriptionDepartment of Anesthesiology and Critical Care Children's Hospital Los Angeles University of Southern California Keck School of Medicine-
Descrição: dc.descriptionDivision of Critical Care Medicine Hospital General de Agudos “C. Durand ” Universidad de Buenos Aires Ciudad Autónoma de Buenos Aires-
Descrição: dc.descriptionEdge Hill University Health Research Institute, England-
Descrição: dc.descriptionDepartment of Surgery and Cancer Faculty of Medicine Imperial College London, England-
Descrição: dc.descriptionDivision of Paediatric Critical Care Medicine Department of Paediatrics Beatrix Children's Hospital University Medical Center Groningen University of Groningen-
Descrição: dc.descriptionPediatric Critical Care Division Department of Pediatrics Cruces University Hospital BioBizkaia Health Research Institute-
Descrição: dc.descriptionDepartment of Pediatrics Sainte-Justine Hospital Université de Montréal-
Descrição: dc.descriptionDepartment of Pediatrics Postgraduate Institute of Medical Education and Research-
Descrição: dc.descriptionWellcome-Wolfson Institute for Experimental Medicine Queen's University Belfast, Northern Ireland-
Descrição: dc.descriptionRuth Lilly Medical Library Indiana University School of Medicine-
Descrição: dc.descriptionFamily and Community Health University of Pennsylvania School of Nursing and Research Institute Children's Hospital of Philadelphia-
Descrição: dc.descriptionDivision of Critical Care Medicine Hospital General de Agudos “C. Durand,” Universidad de Buenos Aires Ciudad Autónoma de Buenos Aires-
Descrição: dc.descriptionDepartment of Pediatrics Pediatric Critical Care Division Botucatu Medical School—UNESP-São Paulo State University, São Paulo-
Descrição: dc.descriptionDivision of Pediatric Cardiology Department of Pediatrics University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center Heart Institute-
Descrição: dc.descriptionRed Colaborativa Pediátrica de Latinoamérica [LARed Network] and Departamento de Pediatría Unidad de Cuidados Intensivos de Niños del Centro Hospitalario Pereira Rossell (UCIN-CHPR) Facultad de Medicina Universidad de la República-
Descrição: dc.descriptionDivision of Critical Care Medicine Department of Pediatrics Seattle Children's Hospital and University of Washington-
Descrição: dc.descriptionDepartment of Anesthesiology and Critical Care Children's Hospital Los Angeles-
Descrição: dc.descriptionDepartment of Anesthesiology and Critical Care Children's Hospital Los Angeles Los Angeles CA and Copenhagen Trial Unit Centre for Clinical Intervention Research The Capital Region of Denmark Rigshospitalet Copenhagen University Hospital-
Descrição: dc.descriptionChildren's Hospital of Philadelphia-
Descrição: dc.descriptionCentre for Human and Applied Physiological Sciences [CHAPS] Faculty of Life Sciences & Medicine King's College London, England-
Descrição: dc.descriptionFlorence Nightingale Faculty of Nursing Midwifery and Palliative Care King's College London, England-
Descrição: dc.descriptionDivision of Pediatric Critical Care Medicine Department of Pediatrics Duke University-
Descrição: dc.descriptionDivision of Pediatric Cardiology Cardiothoracic Intensive Care UC San Diego Rady Children's Hospital-
Descrição: dc.descriptionKK Women's and Children's Hospital-
Descrição: dc.descriptionDepartment of Anesthesiology and Critical Care Children's Hospital Los Angeles University of Southern California and Keck School of Medicine-
Descrição: dc.descriptionDepartment of Pediatrics Pediatric Critical Care Division Botucatu Medical School—UNESP-São Paulo State University, São Paulo-
Formato: dc.format1056-1070-
Idioma: dc.languageen-
Relação: dc.relationChest-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectairway extubation-
Palavras-chave: dc.subjectclinical protocols-
Palavras-chave: dc.subjectmechanical ventilators-
Palavras-chave: dc.subjectpediatric ICUs-
Palavras-chave: dc.subjectventilator weaning-
Título: dc.titleFramework for Research Gaps in Pediatric Ventilator Liberation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.