Effects of remote ischemic conditioning on conditioned pain modulation and cardiac autonomic modulation in women with knee osteoarthritis: placebo-controlled randomized clinical trial protocol

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBiral, Taíse Mendes-
Autor(es): dc.creatorde Souza Cavina, Allysiê Priscilla-
Autor(es): dc.creatorJunior, Eduardo Pizzo-
Autor(es): dc.creatorFilho, Carlos Alberto Toledo Teixeira-
Autor(es): dc.creatorVanderlei, Franciele Marques-
Data de aceite: dc.date.accessioned2025-08-21T16:56:31Z-
Data de disponibilização: dc.date.available2025-08-21T16:56:31Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s13063-023-07527-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304415-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304415-
Descrição: dc.descriptionBackground: It is estimated that over 240 million people worldwide have osteoarthritis, which is a major contributor to chronic pain and central changes in pain processing, including endogenous pain modulation. The autonomic nervous system plays a crucial role in the pain regulatory process. One of the main mechanisms of remote ischemic conditioning is neuronal signaling from the preconditioned extremity to the heart. This study aims to analyze the acute effect of remote ischemic conditioning on local pain, conditioned pain modulation, and cardiac autonomic control in women with knee osteoarthritis and to see if there is a correlation between them. Methods: Women more than 50 years with knee osteoarthritis diagnosed according to the American College of Rheumatology criteria in the postmenopausal period will be considered eligible. The study will have blind randomization, be placebo-controlled, and be balanced in a 1:1 ratio. The total of 44 participants will be divided into two groups (22 participants per group): (i) remote ischemic conditioning and (ii) placebo remote ischemic conditioning. Protocol consisting of four cycles of total ischemia, followed immediately by four cycles of 5 min of vascular reperfusion, totaling 40 min. The primary outcomes in the protocol are conditioned pain modulation, which has the pressure pain threshold (kgf/cm2) as its primary outcome measure, and cardiac autonomic modulation, which has the indices found in heart rate variability as its primary outcome measure. Comparisons will be performed using generalized linear mixed models fitted to the data. For correlation, the Pearson or Spearman test will be used depending on the normality of the data. All analyses will assume a significance level of p < 0.05. Discussion: It is believed that the results of this study will present a new perspective on the interaction between the pain processing system and the cardiovascular system; they will provide the professional and the patient with a greater guarantee of cardiovascular safety in the use of the intervention; it will provide knowledge about acute responses and this will allow future chronic intervention strategies that aim to be used in the clinical environment, inserted in the multimodal approach, for the treatment of osteoarthritis of the knee. Trial registration: ClinicalTrials.gov NCT05059652. Registered on 30 August 2021. Last update on 28 March 2023.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences São Paulo State University (Unesp) School of Technology and Sciences, SP-
Descrição: dc.descriptionPostgraduate Program in Physiotherapy São Paulo State University (Unesp) School of Technology and Sciences, SP-
Descrição: dc.descriptionDepartment of Physiotherapy São Paulo State University (Unesp) School of Technology and Sciences, SP-
Descrição: dc.descriptionPostgraduate Program in Movement Sciences São Paulo State University (Unesp) School of Technology and Sciences, SP-
Descrição: dc.descriptionPostgraduate Program in Physiotherapy São Paulo State University (Unesp) School of Technology and Sciences, SP-
Descrição: dc.descriptionDepartment of Physiotherapy São Paulo State University (Unesp) School of Technology and Sciences, SP-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationTrials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutonomic nervous system-
Palavras-chave: dc.subjectChronic pain-
Palavras-chave: dc.subjectConditioned pain modulation-
Palavras-chave: dc.subjectHeart rate variability-
Palavras-chave: dc.subjectIschemic preconditioning-
Palavras-chave: dc.subjectOsteoarthritis-
Palavras-chave: dc.subjectRandomized controlled trial-
Palavras-chave: dc.subjectTherapeutic occlusion-
Título: dc.titleEffects of remote ischemic conditioning on conditioned pain modulation and cardiac autonomic modulation in women with knee osteoarthritis: placebo-controlled randomized clinical trial protocol-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.