MicroRNA Transcriptomes Reveal Prevalence of Rare and Species-Specific Arm Switching Events During Zebrafish Ontogenesis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Pelotas-
Autor(es): dc.contributorVanderbilt University-
Autor(es): dc.creatorOliveira, Arthur Casulli de-
Autor(es): dc.creatorBovolenta, Luiz Augusto-
Autor(es): dc.creatorFigueiredo, Lucas-
Autor(es): dc.creatorRibeiro, Amanda De Oliveira-
Autor(es): dc.creatorPereira, Beatriz Jacinto Alves-
Autor(es): dc.creatorde Almeida, Talita Roberto Aleixo-
Autor(es): dc.creatorCampos, Vinicius Farias-
Autor(es): dc.creatorPatton, James G-
Autor(es): dc.creatorPinhal, Danillo-
Data de aceite: dc.date.accessioned2025-08-21T20:35:27Z-
Data de disponibilização: dc.date.available2025-08-21T20:35:27Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/11769343241263230-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304363-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304363-
Descrição: dc.descriptionIn metazoans, microRNAs (miRNAs) are essential regulators of gene expression, affecting critical cellular processes from differentiation and proliferation, to homeostasis. During miRNA biogenesis, the miRNA strand that loads onto the RNA-induced Silencing Complex (RISC) can vary, leading to changes in gene targeting and modulation of biological pathways. To investigate the impact of these “arm switching” events on gene regulation, we analyzed a diverse range of tissues and developmental stages in zebrafish by comparing 5p and 3p arms accumulation dynamics between embryonic developmental stages, adult tissues, and sexes. We also compared variable arm usage patterns observed in zebrafish to other vertebrates including arm switching data from fish, birds, and mammals. Our comprehensive analysis revealed that variable arm usage events predominantly take place during embryonic development. It is also noteworthy that isomiR occurrence correlates to changes in arm selection evidencing an important role of microRNA distinct isoforms in reinforcing and modifying gene regulation by promoting dynamics switches on miRNA 5p and 3p arms accumulation. Our results shed new light on the emergence and coordination of gene expression regulation and pave the way for future investigations in this field.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences of Botucatu São Paulo State University-UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University-UNESP, São Paulo-
Descrição: dc.descriptionLaboratory of Structural Genomics Postgraduate Program in Biotechnology Center for Technological Development Federal University of Pelotas, Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Biological Sciences Vanderbilt University-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences of Botucatu São Paulo State University-UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University-UNESP, São Paulo-
Descrição: dc.descriptionCNPq: #136152/2018-0-
Descrição: dc.descriptionCNPq: #167444/2017-4-
Descrição: dc.descriptionFAPESP: #2017/17510-2-
Descrição: dc.descriptionFAPESP: #2018/05484-0-
Descrição: dc.descriptionFAPESP: #2019/15494-5-
Descrição: dc.descriptionCNPq: #315139/2020-0-
Descrição: dc.descriptionCNPq: #433746/2018-1-
Descrição: dc.descriptionCAPES: Finance Code 001-
Idioma: dc.languageen-
Relação: dc.relationEvolutionary Bioinformatics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectarm usage-
Palavras-chave: dc.subjectgene regulation-
Palavras-chave: dc.subjectisomiRs-
Palavras-chave: dc.subjectmicroRNA-
Palavras-chave: dc.subjectnon-coding RNA-
Título: dc.titleMicroRNA Transcriptomes Reveal Prevalence of Rare and Species-Specific Arm Switching Events During Zebrafish Ontogenesis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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