Enhancing photostability and minimizing volatility of a promising drug candidate

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Central de Las Villas (UCLV)-
Autor(es): dc.contributorFederal University of Rio Grande do Norte (UFRN)-
Autor(es): dc.contributorCentral University of Las Villas-
Autor(es): dc.contributorUniversity of Leuven (KULeuven)-
Autor(es): dc.creatorRuz Sanjuan, Vivian-
Autor(es): dc.creatorRibeiro, Clovis Augusto-
Autor(es): dc.creatorRodríguez Chanfrau, Jorge Enrique-
Autor(es): dc.creatorCalvo Alonso, Amalia María-
Autor(es): dc.creatorTabosa do Egito, Evyvaldo Sócrates-
Autor(es): dc.creatorVan den Mooter, Guy-
Autor(es): dc.creatorde Oliveira, Anselmo Gomes-
Data de aceite: dc.date.accessioned2025-08-21T22:45:00Z-
Data de disponibilização: dc.date.available2025-08-21T22:45:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2024.106329-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304356-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304356-
Descrição: dc.descriptionMicroparticles (MP) composed of Ethylcellulose were developed to enhance the photostability and minimize the volatility of the antiprotozoal and antifungal compound 2-(2-nitrovinyl) furan (G-0). MP were prepared using the emulsion solvent evaporation method guided by a factorial design optimization approach. Characterization of the formulations was conducted through Thermal Analysis, FE-SEM microscopy, and X-ray diffraction. Additionally, drug-polymer interactions were analyzed using NMR and FTIR spectroscopy, while drug volatility was assessed by TGA/DTA. Forced photodegradation studies were conducted using a UV-light cabinet, and HPLC was employed for monitoring. The basket method was utilized for the drug release procedure. The resulting MP exhibited spherical morphology, reduced drug crystallinity, and good compatibility, as confirmed by ATR-FTIR and 1H NMR analysis. Microencapsulation led to improved photostability and reduced drug volatilization of G-0. The in vitro release of G-0 from MP was slower compared to the crystalline drug, and the release kinetics were well described by the First-order model. Further investigations will focus on accelerated stability studies on microencapsulated G-0 and compatibility assessments with other excipients to facilitate incorporation in solid formulations.-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Drugs and Medicines School of Pharmaceutical Sciences, Araraquara-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Analytical-Chemistry Chemistry Institute, Araraquara-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Physical-Chemistry Chemistry Institute, Araraquara-
Descrição: dc.descriptionCentro de Bioactivos Quimicos Universidad Central de Las Villas (UCLV), Villa Clara-
Descrição: dc.descriptionPharmacy Department Graduate Program in Health Sciences Federal University of Rio Grande do Norte (UFRN), Rúa Gal. Gustavo Cordeiro de Farias, s/n, Petrópolis, RN-
Descrição: dc.descriptionPharmacy Department Chemistry and Pharmacy Faculty Central University of Las Villas, Carretera a Camajuani Km 5.5, Villa Clara-
Descrição: dc.descriptionDrug Delivery and Disposition Department of Pharmaceutical and Pharmacological Sciences. O&N2 Herestraat 49-Box 921 University of Leuven (KULeuven)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Drugs and Medicines School of Pharmaceutical Sciences, Araraquara-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Analytical-Chemistry Chemistry Institute, Araraquara-
Descrição: dc.descriptionSão Paulo State University (UNESP) Department of Physical-Chemistry Chemistry Institute, Araraquara-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2-(2-nitrovinyl) furan-
Palavras-chave: dc.subjectDrug release-
Palavras-chave: dc.subjectEthylcellulose-
Palavras-chave: dc.subjectMicroparticles-
Palavras-chave: dc.subjectPhotostabilization-
Palavras-chave: dc.subjectVolatilization-
Título: dc.titleEnhancing photostability and minimizing volatility of a promising drug candidate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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