Shortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Talca-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorUniversidad de Antofagasta-
Autor(es): dc.contributorUniversity Medical Centre Groningen (UMCG)-
Autor(es): dc.contributorUniversity Medical Center Groningen (UMCG)-
Autor(es): dc.contributorSocieté des Produits de Nestlé-
Autor(es): dc.contributorTecnologico de Monterrey-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.creatorValero, Paola-
Autor(es): dc.creatorSilva, Katherin-
Autor(es): dc.creatorValenzuela-Hinrichsen, Andrés-
Autor(es): dc.creatorVásquez, Antonia-
Autor(es): dc.creatorEspinoza, Fernanda-
Autor(es): dc.creatorLira, Fernanda-
Autor(es): dc.creatorCornejo, Marcelo-
Autor(es): dc.creatorFuentes, Gonzalo-
Autor(es): dc.creatorGonzález, Daniel-
Autor(es): dc.creatorMoore-Carrasco, Rodrigo-
Autor(es): dc.creatorvan der Beek, Eline M.-
Autor(es): dc.creatorHillebrands, Jan-Luuk-
Autor(es): dc.creatorvan Goor, Harry-
Autor(es): dc.creatorGrismaldo, Adriana-
Autor(es): dc.creatorSobrevia, Luis-
Data de aceite: dc.date.accessioned2025-08-21T15:26:07Z-
Data de disponibilização: dc.date.available2025-08-21T15:26:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1113/JP286955-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304338-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304338-
Descrição: dc.descriptionExtracellular vesicles (EVs) play a crucial role in mediating communication between cells across species and kingdoms. The intercellular communication facilitated by EVs through autocrine and paracrine signalling mechanisms is essential for cell survival, maintaining normal metabolic functions and ensuring overall bodily homeostasis and health. Extracellular vesicles are present in various bodily fluids, such as pleural effusions, plasma, breast milk, amniotic fluid, semen and saliva. Additionally, the generation and release of EVs contribute to the removal of cellular waste. Patients with obesity exhibit a higher release and amount of circulating EVs than individuals with normal weight. This increased EV release in obesity might contribute to the inflammatory state characteristic of this metabolic condition, because higher levels of pro-inflammatory molecules are found within their cargo. However, interpreting results related to EV abundance, cargo and biological actions can be complicated by several factors; these include variations in cell sources, a wide age range (from children to the elderly), a mix of females and males, medication use and health status, a range of body weights (from normal weight to morbid obesity) and differences between in vitro assays using cell lines versus primary cultures. This article addresses the shortcomings, limitations and gaps in knowledge, providing a framework for enhancing our understanding of the physiological effects of EVs on obesity. (Figure presented.).-
Descrição: dc.description**Cellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionFaculty of Health Sciences Universidad de Talca-
Descrição: dc.descriptionInstitute of Chemistry Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionFaculty of Medicine Universidad de Antofagasta-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology Division of Pathology University of Groningen University Medical Centre Groningen (UMCG)-
Descrição: dc.descriptionBiomedical Department Faculty of Health Sciences Universidad de Antofagasta-
Descrição: dc.descriptionDepartment of Pediatrics University of Groningen University Medical Center Groningen (UMCG)-
Descrição: dc.descriptionNestlé Institute for Health Sciences Nestlé Research Societé des Produits de Nestlé-
Descrição: dc.description**Faculty of Excellence program School of Medicine and Health Sciences The Institute for Obesity Research (IOR) Eutra Tecnologico de Monterrey, Nuevo León-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP), Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectage-
Palavras-chave: dc.subjectexosomes-
Palavras-chave: dc.subjectextracellular vesicles-
Palavras-chave: dc.subjecthuman-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectsex-
Título: dc.titleShortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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