Analysis of pulp histological response to pulpotomy performed with white mineral trioxide aggregate mixed with 2.25% sodium hypochlorite gel in humans: a randomized controlled clinical trial

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Autor(es): dc.contributorDamascus University-
Autor(es): dc.contributorAtomic Energy Commission-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Espíritu Santo-
Autor(es): dc.contributorKyung Hee University-
Autor(es): dc.contributorKyung Hee University Medical Center-
Autor(es): dc.creatorKarkoutly, Mawia-
Autor(es): dc.creatorAlnour, Amirah-
Autor(es): dc.creatorAlabdullah, Jamal-
Autor(es): dc.creatorAbu Hasna, Amjad-
Autor(es): dc.creatorNam, Ok Hyung-
Autor(es): dc.creatorJalloul, Darin-
Autor(es): dc.creatorAl Kurdi, Saleh-
Autor(es): dc.creatorBshara, Nada-
Data de aceite: dc.date.accessioned2025-08-21T18:33:46Z-
Data de disponibilização: dc.date.available2025-08-21T18:33:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-024-83158-0-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304302-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304302-
Descrição: dc.descriptionThis study aimed to evaluate the histological success of pulpotomy in primary molars using white mineral trioxide aggregate (WMTA) mixed with 2.25% sodium hypochlorite (NaOCl) gel and to evaluate in vitro its physical and chemical properties. The study had a clinical stage and an in-vitro stage. The clinical study was conducted with 24 patients aged 8–10 years. It was a randomized controlled trial to perform a histologic evaluation of pulp response following pulpotomy. Primary first molars were randomly assigned in split mouth model to control group—WMTA + distilled water (DW) or experimental group – WMTA + NaOCl gel. Teeth were extracted after 7, 30 or 90 days and submitted to histological analysis. The second stage was an in-vitro study to evaluate the physical and chemical properties of the two materials tested. SEM and EDX analyses and pH level evaluations were performed after 24 h and 28 days. The histological findings revealed that while WMTA + NaOCl gel group showed better odontoblastic integrity (P < 0.05), WMTA + DW group had more favorable outcomes in dentin bridge formation and pulp calcification (P < 0.05). Pulp tissue hemorrhage and pulp fibrosis were similar between them (P > 0.05). Regarding materials’ in vitro evaluation, the pH level indicated a higher initial pH for the WMTA + NaOCl gel group, which equalized after 28 days. SEM analysis initially showed a less homogeneous surface for WMTA + NaOCl gel, but it became similar after 28 days. EDX analysis indicated higher calcium and silicon percentages in the WMTA + NaOCl gel group initially, which increased in both groups after 28 days. Adding 2.25% NaOCl gel to WMTA enhanced odontoblastic integrity in both the short and medium term. In addition, it had a similar chemical composition, surface morphology, and alkalinity when compared to WMTA + DW mixture.-
Descrição: dc.descriptionDepartment of Pediatric Dentistry Faculty of Dentistry Damascus University-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Pathology Faculty of Dentistry Damascus University-
Descrição: dc.descriptionDepartment of Protection and Safety Atomic Energy Commission, P.O. Box 6091-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), Eng. Francisco José Longo Avenue 777, São Paulo-
Descrição: dc.descriptionSchool of Dentistry Universidad Espíritu Santo-
Descrição: dc.descriptionDepartment of Pediatric Dentistry School of Dentistry Kyung Hee University-
Descrição: dc.descriptionDepartment of Pediatric Dentistry Kyung Hee University College of Dentistry Kyung Hee University Medical Center-
Descrição: dc.descriptionDepartment of Operative Dentistry and Endodontics Faculty of Dentistry Damascus University-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), Eng. Francisco José Longo Avenue 777, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMineral trioxide aggregate-
Palavras-chave: dc.subjectPulpotomy-
Palavras-chave: dc.subjectSodium hypochlorite gel-
Título: dc.titleAnalysis of pulp histological response to pulpotomy performed with white mineral trioxide aggregate mixed with 2.25% sodium hypochlorite gel in humans: a randomized controlled clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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