ENDOCANNABINOID SYSTEM IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS MODULATES AUTONOMIC AND CARDIOVASCULAR CHANGES BUT NOT VASOPRESSIN RESPONSE IN A RAT HEMORRHAGIC SHOCK MODEL

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMassachusetts General Hospital and Harvard Medical School-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFaculty of Medicine.Federal University of Lavras-
Autor(es): dc.creatorBusnardo, Cristiane-
Autor(es): dc.creatorFassini, Aline-
Autor(es): dc.creatorLopes-Azevedo, Silvana-
Autor(es): dc.creatorOmena-Giatti, Luana-
Autor(es): dc.creatorGoulart, Melissa T.-
Autor(es): dc.creatorAntunes-Rodrigues, Jose-
Autor(es): dc.creatorAlves, Fernando H. F.-
Autor(es): dc.creatorCorrea, Fernando M. A.-
Autor(es): dc.creatorCrestani, Carlos C.-
Data de aceite: dc.date.accessioned2025-08-21T17:42:18Z-
Data de disponibilização: dc.date.available2025-08-21T17:42:18Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/SHK.0000000000002286-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304285-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304285-
Descrição: dc.descriptionWe evaluated the participation of the endocannabinoid systemin the paraventricular nucleus of the hypothalamus (PVN) on the cardiovascular, autonomic, and plasma vasopressin (AVP) responses evoked by hemorrhagic shock in rats. For this, the PVN was bilaterally treated with either vehicle, the selective cannabinoid receptor type 1 antagonist AM251, the selective fatty acid amide hydrolase amide enzyme inhibitor URB597, the selective monoacylglycerol-lipase enzyme inhibitor JZL184, or the selective transient receptor potential vanilloid type 1 antagonist capsazepine. We evaluated changes on arterial pressure, heart rate, tail skin temperature (ST), and plasma AVP responses induced by bleeding, which started 10 min after PVN treatment. We observed that bilateral microinjection of AM251 into the PVN reduced the hypotension during the hemorrhage and prevented the return of blood pressure to baseline values in the posthemorrhagic period. Inhibition of local 2-arachidonoylglycerol metabolism by PVN treatment with JZL184 induced similar effects in relation to those observed in AM251-treated animals. Inhibition of local anandamidemetabolism via PVNtreatment with URB597 decreased the depressor effect and ST drop induced by the hemorrhagic stimulus. Bilateral microinjection of capsazepine mitigated the fall in blood pressure and ST. None of the PVN treatments altered the increased plasma concentration of AVP and tachycardia induced by hemorrhage. Taken together, present results suggest that endocannabinoid neurotransmission within the PVN plays a prominent role in cardiovascular and autonomic, but not neuroendocrine, responses evoked by hemorrhage.-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences Sao Paulo State University (UNESP), Araraquara-
Descrição: dc.descriptionDepartment of Neurology MassGeneral Institute of Neurodegenerative Diseases Massachusetts General Hospital and Harvard Medical School-
Descrição: dc.descriptionDepartment of Pharmacology School of Medicine of Ribeirao Preto University of Sao Paulo, Ribeirao Preto-
Descrição: dc.descriptionDepartment of Health Sciences Faculty of Medicine.Federal University of Lavras, Minas Gerais-
Descrição: dc.descriptionDepartment of Physiology School of Medicine of Ribeirao Preto University of Sao Paulo, Ribeirao Preto-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceutics School of Pharmaceutical Sciences Sao Paulo State University (UNESP), Araraquara-
Formato: dc.format294-303-
Idioma: dc.languageen-
Relação: dc.relationShock-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndocannabinoid-
Palavras-chave: dc.subjecthemorrhagic shock-
Palavras-chave: dc.subjecthypothalamus, cardiovascular-
Palavras-chave: dc.subjectsympathetic activity-
Palavras-chave: dc.subjectvasopressin-
Título: dc.titleENDOCANNABINOID SYSTEM IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS MODULATES AUTONOMIC AND CARDIOVASCULAR CHANGES BUT NOT VASOPRESSIN RESPONSE IN A RAT HEMORRHAGIC SHOCK MODEL-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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