Detection and Analysis of Florfenicol Residues and Metabolites in Nile Tilapia (Oreochromis niloticus) Tissues Post-Oral Administration in Tropical Waters

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHelmholtz Zentrum München-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorZambeze University (UniZambeze)-
Autor(es): dc.creatorQueiroga, Anna Paula R.-
Autor(es): dc.creatorSouza, Gabriela F. P.-
Autor(es): dc.creatorPaschoal, Jonas Augusto R.-
Autor(es): dc.creatorSalles, Airton Gonçalves-
Autor(es): dc.creatorSchloter, Michael-
Autor(es): dc.creatorAssane, Inácio Mateus-
Autor(es): dc.creatorPilarski, Fabiana-
Autor(es): dc.creatorGotardo, André Tadeu-
Autor(es): dc.creatorGórniak, Silvana Lima-
Autor(es): dc.creatorRath, Susanne-
Data de aceite: dc.date.accessioned2025-08-21T19:38:04Z-
Data de disponibilização: dc.date.available2025-08-21T19:38:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jvp.13485-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304256-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304256-
Descrição: dc.descriptionWater temperature is a critical environmental parameter that significantly influences fish metabolism. This study assessed the metabolism of florfenicol (FF) in tilapia (Oreochromis niloticus) at water temperatures typical of tropical and subtropical regions. Fish were treated with FF by oral administration of a dose of 10 mg kg−1 bw for 10 consecutive days. Fish fillet, liver, and kidney were sampled during the treatment phase (1, 5, and 10 days) and posttreatment (1, 2, 3, and 5 days after the last FF administration). FF, florfenicol amine (FFA), monochloro florfenicol (FFCl), and florfenicol alcohol (FFOH) were determined in the sampled tissues using a validated LC–LC–MS/MS method. The highest FF, FFA, and FFOH concentrations were determined on day 5 during the treatment phase. For FF, the concentration order is kidney > liver > fillet, while for the metabolites FFOH and FFA, the order is liver > kidney > fillet. In fillet and liver, the concentrations of FFOH were higher than the FFA concentrations, indicating that FFOH was the primary metabolite in these tissues. FFCl was only quantified at concentrations lower than 90 μg kg−1 in all tissues. The results indicated that FF can be readily absorbed and rapidly eliminated in tilapia cultivated in warm water environments. This study revealed FFOH as the primary and most persistent metabolite in tilapia farmed in warm water, followed by FFA.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstitute of Chemistry University of Campinas, São Paulo-
Descrição: dc.descriptionDepartment of Biomolecular Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionComparative Microbiome Analysis Research Unit Helmholtz Zentrum München-
Descrição: dc.descriptionLaboratory of Microbiology and Parasitology of Aquatic Organisms Aquaculture Center of UNESP São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionAnimal Health Laboratory Faculty of Agricultural Sciences Zambeze University (UniZambeze), Tete-
Descrição: dc.descriptionDepartment of Pathology Research Centre for Veterinary Toxicology (CEPTOX) School of Veterinary Medicine and Animal Science University of São Paulo, São Paulo-
Descrição: dc.descriptionLaboratory of Microbiology and Parasitology of Aquatic Organisms Aquaculture Center of UNESP São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2019/22775-0-
Descrição: dc.descriptionFAPESP: 2021/08152-0-
Descrição: dc.descriptionFAPESP: 2022/00343-4-
Descrição: dc.descriptionFAPESP: 2022/08804-0-
Descrição: dc.descriptionCNPq: 304584/2021-5-
Formato: dc.format110-122-
Idioma: dc.languageen-
Relação: dc.relationJournal of Veterinary Pharmacology and Therapeutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectflorfenicol metabolites-
Palavras-chave: dc.subjectNile tilapia-
Palavras-chave: dc.subjectpharmacokinetics-
Palavras-chave: dc.subjectresidues-
Palavras-chave: dc.subjectwarm water-
Título: dc.titleDetection and Analysis of Florfenicol Residues and Metabolites in Nile Tilapia (Oreochromis niloticus) Tissues Post-Oral Administration in Tropical Waters-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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