Gymnema sylvestre as a Potential Anti-Inflammatory and Anti-Biofilm Agent Against Anaerobic Infections: An In Vitro Study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospices Civils de Lyon-
Autor(es): dc.contributorUniversity of Lyon-
Autor(es): dc.contributorPaulista University-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorUniversity of Leeds-
Autor(es): dc.contributorUniversity of Vale do Paraíba-
Autor(es): dc.contributorFederal University of Alfenas—UNIFAL-
Autor(es): dc.creatorMiranda, Diego Garcia-
Autor(es): dc.creatorTomé, Fernanda Malagutti-
Autor(es): dc.creatorMiguel, Manuela Maria Viana-
Autor(es): dc.creatorLiberato, Sabrina Ferreira dos Santos-
Autor(es): dc.creatorMarcucci, Maria Cristina-
Autor(es): dc.creatorVigerelli, Hugo-
Autor(es): dc.creatorRodrigues, Flavia Pires-
Autor(es): dc.creatorPacheco-Soares, Cristina-
Autor(es): dc.creatorGodoi, Bruno Henrique-
Autor(es): dc.creatorCarrouel, Florence-
Autor(es): dc.creatorde Oliveira, Luciane Dias-
Autor(es): dc.creatorRamos, Lucas de Paula-
Data de aceite: dc.date.accessioned2025-08-21T19:07:40Z-
Data de disponibilização: dc.date.available2025-08-21T19:07:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/plants14040497-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304201-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304201-
Descrição: dc.descriptionThis study evaluates the antimicrobial activity of the glycolic extract of G. sylvestre against anaerobic pathogens, along with its cytotoxicity, genotoxicity, anti-inflammatory activity, antioxidant effects, and phytochemical composition. Phytochemical analysis was conducted using high-performance liquid chromatography and liquid chromatography–mass spectrometry, while the antioxidant effect was assessed through a DPPH assay. Antimicrobial action was tested on planktonic cultures and biofilms of Porphyromonas gingivalis, Porphyromonas endodontalis, Parvimonas micra, and Fusobacterium nucleatum. Cytotoxicity was evaluated using mouse macrophages (RAW 264.7), rat fibroblasts (L929), and human keratinocytes (HaCaT). Anti-inflammatory effects were measured by an immunoenzymatic assay (ELISA) on RAW 264.7 cells. Statistical analysis was performed using a one-way ANOVA and Tukey’s test. Phytochemical analysis revealed the presence of phenolic compounds and flavonoids. The extract demonstrated a reduction of over 95% in biofilms of P. gingivalis, P. micra, and F. nucleatum within 5 min of treatment. Cell viability (HaCaT) remained above 80%. Antioxidant activity showed an EC50 of 353.43 µg/mL, achieving a 50% reduction in free radicals. A significant decrease in TNF-α (a pro-inflammatory cytokine) and an increase in IL-10 (an anti-inflammatory cytokine) were observed. In conclusion, the extract of G. sylvestre exhibits promising potential as a therapeutic agent for treating anaerobic infections, inflammation, and oxidative stress.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), Francisco José Longo 777, São Dimas, SP-
Descrição: dc.descriptionNeonatology and Neonatal Resuscitation Service Woman-Mother-Child Hospital Hospices Civils de Lyon, 59 Boulevard Pinel-
Descrição: dc.descriptionMultimaterials and Interfaces Laboratory (LMI) CNRS UMR 5615 University Claude Bernard Lyon 1 University of Lyon, 6 rue Victor Grignard-
Descrição: dc.descriptionLaboratory “Health Systemic Process” (P2S) UR4129 Faculty of Medicine Laennec University Claude Bernard Lyon 1 University of Lyon, 7 rue Guillaume Paradin-
Descrição: dc.descriptionDepartment of Health Sciences Paulista University, Highway President Dutra km 157, São José dos Campos 12240-420, SP-
Descrição: dc.descriptionCenter of Excellence in New Target Discovery Butantan Institute, SP-
Descrição: dc.descriptionFaculty of Medicine and Health School of Dentistry Oral Biology Division University of Leeds-
Descrição: dc.descriptionLaboratory of Cell Compartment Dynamics Institute of Research and Development University of Vale do Paraíba, Av. Shishima Hifumi 2911, São José dos Campos 12244-000, SP-
Descrição: dc.descriptionSchool of Dentistry Federal University of Alfenas—UNIFAL, R. Gabriel Monteiro da Silva, 700—CentroMG-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), Francisco José Longo 777, São Dimas, SP-
Idioma: dc.languageen-
Relação: dc.relationPlants-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-inflammatory agents-
Palavras-chave: dc.subjectantimicrobial agents-
Palavras-chave: dc.subjectbiofilms-
Palavras-chave: dc.subjectGram-negative anaerobic cocci-
Título: dc.titleGymnema sylvestre as a Potential Anti-Inflammatory and Anti-Biofilm Agent Against Anaerobic Infections: An In Vitro Study-
Tipo de arquivo: dc.typelivro digital-
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