Effects of concurrent training and N-acetylcysteine supplementation on cardiac remodeling and oxidative stress in middle-aged spontaneously hypertensive rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso Do Sul-
Autor(es): dc.contributorUniversity of Western Sao Paulo-
Autor(es): dc.creatorJunqueira, Adriana-
Autor(es): dc.creatorGomes, Mariana J.-
Autor(es): dc.creatorLima, Aline R. R.-
Autor(es): dc.creatorPontes, Thierres H. D.-
Autor(es): dc.creatorRodrigues, Eder A.-
Autor(es): dc.creatorDamatto, Felipe C.-
Autor(es): dc.creatorDepra, Igor-
Autor(es): dc.creatorPaschoareli, Guilherme L.-
Autor(es): dc.creatorPagan, Luana U.-
Autor(es): dc.creatorFernandes, Ana A. H.-
Autor(es): dc.creatorOliveira-Jr, Silvio A.-
Autor(es): dc.creatorPacagnelli, Francis L.-
Autor(es): dc.creatorOkoshi, Marina P.-
Autor(es): dc.creatorOkoshi, Katashi-
Data de aceite: dc.date.accessioned2025-08-21T16:04:55Z-
Data de disponibilização: dc.date.available2025-08-21T16:04:55Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12872-024-04075-8-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304187-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304187-
Descrição: dc.descriptionBackground: This study evaluated the effects of concurrent isolated training (T) or training combined with the antioxidant N-acetylcysteine (NAC) on cardiac remodeling and oxidative stress in spontaneously hypertensive rats (SHR). Methods: Six-month-old male SHR were divided into sedentary (S, n = 12), concurrent training (T, n = 13), sedentary supplemented with NAC (SNAC, n = 13), and concurrent training with NAC supplementation (TNAC, n = 14) groups. T and TNAC rats were trained three times a week on a treadmill and ladder; NAC supplemented groups received 120 mg/kg/day NAC in rat chow for eight weeks. Myocardial antioxidant enzyme activity and lipid hydroperoxide concentration were assessed by spectrophotometry. Gene expression of NADPH oxidase subunits Nox2, Nox4, p22 phox, and p47 phox was evaluated by real time RT-PCR. Statistical analysis was performed using ANOVA and Bonferroni or Kruskal–Wallis and Dunn. Results: Echocardiogram showed concentric remodeling in TNAC, characterized by increased relative wall thickness (S 0.40 ± 0.04; T 0.39 ± 0.03; SNAC 0.40 ± 0.04; TNAC 0.43 ± 0.04 *; * p < 0.05 vs T and SNAC) and diastolic posterior wall thickness (S 1.50 ± 0.12; T 1.52 ± 0.10; SNAC 1.56 ± 0.12; TNAC 1.62 ± 0.14 * mm; * p < 0.05 vs T), with improved contractile function (posterior wall shortening velocity: S 39.4 ± 5.01; T 36.4 ± 2.96; SNAC 39.7 ± 3.44; TNAC 41.6 ± 3.57 * mm/s; * p < 0.05 vs T). Myocardial lipid hydroperoxide concentration was lower in NAC treated groups (S 210 ± 48; T 182 ± 43; SNAC 159 ± 33 *; TNAC 110 ± 23 *# nmol/g tissue; * p < 0.05 vs S, #p < 0.05 vs T and SNAC). Nox 2 and p22 phox expression was higher and p47 phox lower in T than S [S 1.37 (0.66–1.66); T 0.78 (0.61–1.04) *; SNAC 1.07 (1.01–1.38); TNAC 1.06 (1.01–1.15) arbitrary units; * p < 0.05 vs S]. NADPH oxidase subunits did not differ between TNAC, SNAC, and S groups. Conclusion: N-acetylcysteine supplementation alone reduces oxidative stress in untreated spontaneously hypertensive rats. The combination of N-acetylcysteine and concurrent exercise further decreases oxidative stress. However, the lower oxidative stress does not translate into improved cardiac remodeling and function in untreated spontaneously hypertensive rats.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionFederal University of Mato Grosso Do Sul, MS-
Descrição: dc.descriptionPhysiotherapy Department University of Western Sao Paulo, SP-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionFAPESP: 2021/10923-5-
Descrição: dc.descriptionCNPq: 307280/2022-5-
Descrição: dc.descriptionCNPq: 307703/2022-3-
Idioma: dc.languageen-
Relação: dc.relationBMC Cardiovascular Disorders-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArterial hypertension-
Palavras-chave: dc.subjectCardiac function-
Palavras-chave: dc.subjectEchocardiogram-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPhysical exercise-
Palavras-chave: dc.subjectSHR-
Título: dc.titleEffects of concurrent training and N-acetylcysteine supplementation on cardiac remodeling and oxidative stress in middle-aged spontaneously hypertensive rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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