Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculty of Pharmacy & Pharmaceutical Sciences-
Autor(es): dc.creatorde Souza, Aline-
Autor(es): dc.creatorScarim, Cauê Benito-
Autor(es): dc.creatorCotrim, Paulo Cesar-
Autor(es): dc.creatorJunior, Fernando Barbosa-
Autor(es): dc.creatorRocha, Bruno Alves-
Autor(es): dc.creatorCalixto, Leandro Augusto-
Autor(es): dc.creatorCorreia, Cristiano Jesus-
Autor(es): dc.creatorde Barros Araújo, Gabriel Lima-
Autor(es): dc.creatorLöbenberg, Raimar-
Autor(es): dc.creatorBou-Chacra, Nádia Araci-
Autor(es): dc.creatorBreithaupt-Faloppa, Ana Cristina-
Data de aceite: dc.date.accessioned2025-08-21T18:02:46Z-
Data de disponibilização: dc.date.available2025-08-21T18:02:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/nnm-2023-0263-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304183-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304183-
Descrição: dc.descriptionBackground: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 μg/ml, respectively. After chylomicron blocking, NFOH was not detected. Conclusion: Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Drugs & Medicines School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionSeroepidemiology Cellular & Molecular Immunology Laboratory Institute of Tropical Medicine University of São Paulo, Dr. Enéas de Carvalho Aguiar 470, Jardim América, SP-
Descrição: dc.descriptionLaboratory of Toxicology & Essentiality of Metals Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo, SP-
Descrição: dc.descriptionFederal University of São Paulo Department of Pharmaceutical Sciences Institute of Environmental Chemical & Pharmaceutical Sciences, SP-
Descrição: dc.descriptionLaboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11) Instituto do Coração (InCor) Faculdade de Medicina Universidade de São Paulo-
Descrição: dc.descriptionUniversity of Alberta Faculty of Pharmacy & Pharmaceutical Sciences-
Descrição: dc.descriptionDepartment of Drugs & Medicines School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionFAPESP: 2017/08332-3-
Formato: dc.format293-301-
Idioma: dc.languageen-
Relação: dc.relationNanomedicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchylomicrons-
Palavras-chave: dc.subjectcycloheximide-
Palavras-chave: dc.subjecthydroxymethylnitrofurazone-
Palavras-chave: dc.subjectlymphatic system-
Palavras-chave: dc.subjectnanostructured lipid carrier-
Título: dc.titleHydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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