Influence of anti-sclerostin monoclonal antibody in the repair of post-extraction sockets of ovariectomized rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMarcantonio, Camila Chierici-
Autor(es): dc.creatorPerles, Gabriel Henrique-
Autor(es): dc.creatorLopes, Maria Eduarda Scordamaia-
Autor(es): dc.creatorSoares, Lélio Fernando Ferreira-
Autor(es): dc.creatorda Costa, Paulo Inácio-
Autor(es): dc.creatorCerri, Paulo Sergio-
Autor(es): dc.creatorCirelli, Joni Augusto-
Data de aceite: dc.date.accessioned2025-08-21T22:04:30Z-
Data de disponibilização: dc.date.available2025-08-21T22:04:30Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2024.105962-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304166-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304166-
Descrição: dc.descriptionObjective: This study assessed the impact of an anti-sclerostin monoclonal antibody (Scl-Ab)-based osteoporosis drug on the post-extraction alveolar repair of ovariectomized rats. Design: Fifteen female rats were randomly distributed into three groups: CTR (healthy animals), OST (osteoporosis induced by ovariectomy), and OST+Scl-Ab (osteoporosis induction followed by Scl-Ab treatment). Ovariectomy or sham surgery was performed 30 days before baseline, and Scl-Ab or a vehicle was administered accordingly in the groups. After seven days, all rats underwent the first lower molar extraction and were euthanized 15 days later. Computed microtomography, histological analysis, and collagen content measurement were performed on post-extraction sockets and intact mandibular and maxillary bone areas. Results: Microtomographic analyses of the sockets and mandibles did not reveal significant differences between groups on bone morphometric parameters (p > 0.05), while maxillary bone analyses resulted in better maintenance of bone architecture in OST+Scl-Ab, compared to OST (p < 0.05). Descriptive histological analysis and polarization microscopy indicated better post-extraction socket repair characteristics and collagen content in OST+Scl-Ab compared to OST (p < 0.05). Conclusions: Scl-Ab-based medication did not accelerate alveolar bone formation but exhibited better post-extraction repair characteristics, and collagen content compared to ovariectomized animals only.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Morphology Laboratory of Histology and Embryology School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Morphology Laboratory of Histology and Embryology School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionFAPESP: 2021/10829-9-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibodies-
Palavras-chave: dc.subjectOsteoporosis-
Palavras-chave: dc.subjectRomosozumab-
Palavras-chave: dc.subjectTooth Extraction-
Palavras-chave: dc.subjectTooth Socket-
Título: dc.titleInfluence of anti-sclerostin monoclonal antibody in the repair of post-extraction sockets of ovariectomized rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.