Development of a natural rubber latex-based biodevice with mesenchymal stem cells as a potential treatment for skeletal muscle regeneration in gestational diabetes-induced myopathy

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorImperial College London-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.contributorUniversity Medical Center Groningen-
Autor(es): dc.contributorSchool of Medicine and Health Sciences-
Autor(es): dc.contributorFederal Institute of São Paulo (IFSP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorCollege of Health and Human Development-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatorBarbosa, Angélica Mércia Pascon-
Autor(es): dc.creatorEmanueli, Costanza-
Autor(es): dc.creatorde Lima, Patrícia Rodrigues-
Autor(es): dc.creatorde Oliveira, Rafael Guilen-
Autor(es): dc.creatorDe Carvalho, Carolina Neiva Frota-
Autor(es): dc.creatorFloriano, Emerson Aparecido Ferreira-
Autor(es): dc.creatorZambuzzi, Willian Fernando-
Autor(es): dc.creatorPinto, Thaís Silva-
Autor(es): dc.creatorFernandes, Fábio Henrique-
Autor(es): dc.creatorSalvadori, Daisy Maria Favero-
Autor(es): dc.creatorMagalhães, Phillipe Franklin Coelho-
Autor(es): dc.creatorAlbano, Luiz Gustavo Simão-
Autor(es): dc.creatorde Oliveira Graeff, Carlos Frederico-
Autor(es): dc.creatorSant'Ana Pegorin Brasil, Giovana-
Autor(es): dc.creatordos Santos, Lindomar Soares-
Autor(es): dc.creatorBurd, Betina Sayeg-
Autor(es): dc.creatorCao, Wei-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorde Assis Golim, Marjorie-
Autor(es): dc.creatorFerreira Junior, Rui Seabra-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorRudge, Marilza Vieira Cunha-
Data de aceite: dc.date.accessioned2025-08-21T21:36:58Z-
Data de disponibilização: dc.date.available2025-08-21T21:36:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2024.138777-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304152-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304152-
Descrição: dc.descriptionWomen with gestational diabetes mellitus show a high risk of developing Gestational Diabetes Induced Myopathy (GDiM). GDiM is characterized by significant pelvic floor skeletal muscle atrophy and urinary incontinence. This study aimed to develop a natural rubber latex (NRL) based biodevice with mesenchymal/stromal stem cells (MSCs) for skeletal muscle regeneration for women with GDiM. NRL showed porosity, roughness, biocompatibility, and bioactivity. MSCs adhesion on the NRL scaffold surface was assessed by scanning electron microscopy (SEM), confocal microscopy, and zymography. The scaffold's physicochemical and biological properties were carried out by Fourier transform infrared spectroscopy (FTIR), swelling and degradation studies, hemolytic activity, and antioxidant activity (AA), using Electronic Paramagnetic Resonance (EPR). MSCs in culture expressed CD90, adhered to plastic, differentiated, and produced fibroblast colonies. A high rate of cell proliferation was seen in MSCs on the NRL scaffold. FTIR analysis confirmed protein structures and polyisoprene in the scaffold. Swelling and degradation showed low water uptake and weight loss. Furthermore, NRL presented a hemolytic rate of 2.90 ± 0.26 % for 24 h, and EPR revealed the scaffold's strong AA. The generated biodevice has potential for muscle regeneration and may be useful as a therapeutic option for skeletal muscle disorders in GDiM or urinary incontinence.-
Descrição: dc.descriptionPontificia Universidad Católica de Chile-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School (FMB), São Paulo-
Descrição: dc.descriptionNational Heart and Lung Institute Imperial College London-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland, Herston-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Philosophy and Sciences, São Paulo-
Descrição: dc.descriptionTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences, Nuevo León-
Descrição: dc.descriptionFederal Institute of São Paulo (IFSP), São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioscienses Institute Bioassays & Cell Dynam Lab Dept Chem & Biochem, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bauru School of Sciences (FC), São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences (FCF), São Paulo-
Descrição: dc.descriptionUniversity of São Paulo (USP) Faculty of Philosophy Sciences and Languages of Ribeirão Preto, 3900 Bandeirantes Avenue, SP-
Descrição: dc.descriptionCalifornia State University Northridge (CSUN) College of Health and Human Development-
Descrição: dc.descriptionSão Paulo State University (UNESP) Center for the Study of Venoms and Venomous Animals (CEVAP), São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School (FMB), São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Philosophy and Sciences, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioscienses Institute Bioassays & Cell Dynam Lab Dept Chem & Biochem, São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bauru School of Sciences (FC), São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences (FCF), São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) Center for the Study of Venoms and Venomous Animals (CEVAP), São Paulo-
Descrição: dc.descriptionFAPESP: 2016/01743-5-
Descrição: dc.descriptionFAPESP: 2017/21783-4-
Descrição: dc.descriptionFAPESP: 2018/22406-2-
Descrição: dc.descriptionPontificia Universidad Católica de Chile: 220723001-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiodevice-
Palavras-chave: dc.subjectBone marrow-derived mesenchymal stromal/stem cells-
Palavras-chave: dc.subjectGestational diabetes-
Palavras-chave: dc.subjectGestational diabetes induced myopathy-
Palavras-chave: dc.subjectNatural rubber latex-
Palavras-chave: dc.subjectSkeletal muscle-
Título: dc.titleDevelopment of a natural rubber latex-based biodevice with mesenchymal stem cells as a potential treatment for skeletal muscle regeneration in gestational diabetes-induced myopathy-
Tipo de arquivo: dc.typelivro digital-
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