Is there an effective way to control pain perception after free gingival graft removal? A systematic review and meta-analysis

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Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.contributorUniversity of Taubaté-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorThe Forsyth Institute-
Autor(es): dc.creatorAmeida, Flavio X.-
Autor(es): dc.creatorCotrim, Khalila C.-
Autor(es): dc.creatorKalil, Eduardo C.-
Autor(es): dc.creatorBechara, Karen-
Autor(es): dc.creatorDalla, Renan-
Autor(es): dc.creatorRovai, Emanuel S.-
Autor(es): dc.creatorShibli, Jamil A.-
Autor(es): dc.creatorCastro Dos Santos, Nidia C.-
Data de aceite: dc.date.accessioned2025-08-21T15:51:06Z-
Data de disponibilização: dc.date.available2025-08-21T15:51:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0103-6440202305503-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304133-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304133-
Descrição: dc.descriptionThe literature describes multiple ways to stimulate wound healing to reduce the patient's perception of pain. This systematic review aimed to evaluate if methods that enhance wound healing can reduce the patient's perception of pain after free gingival graft removal from the palate region compared to natural healing. A systematic review protocol was written following the PRISMA checklist. Electronic searches of five databases were performed to identify randomized clinical trials (RCTs) that assessed the patient's perception of pain after the removal of a free gingival graft from the palate. The primary outcome was the visual analog scale (VAS) score assessing the patient's perception of pain 7 days after the free gingival graft removal from the palate region. Of the 1,622 potentially relevant articles retrieved from the electronic databases, 16 RCTs were selected for qualitative analysis, and of these, 6 RCTs were included in the meta-analysis. RCTs showed a significant VAS reduction associated with the use of methods to enhance wound healing. The pooled estimates revealed a significant overall VAS reduction of 2.20 (95% Cl 2.32, 2.07) 7 days after surgery. The methods that presented the greatest reduction in the perception of pain were platelet-rich fibrin, hyaluronic acid, and autologous fibrin glue. Methods that enhance wound healing, including platelet-rich fibrin, hyaluronic acid, and autologous fibrin glue, can reduce pain perception after free gingival graft removal in the palate region. However, only 1 RCT investigated each approach, which hinders the conclusion regarding the best procedure to reduce the perception of pain. The literature describes multiple ways to stimulate wound healing to reduce the patient's perception of pain. This systematic review aimed to evaluate if methods that enhance wound healing can reduce the patient's perception of pain after free gingival graft removal from the palate region compared to natural healing. A systematic review protocol was written following the PRISMA checklist. Electronic searches of five databases were performed to identify randomized clinical trials (RCTs) that assessed the patient's perception of pain after the removal of a free gingival graft from the palate. The primary outcome was the visual analog scale (VAS) score assessing the patient's perception of pain 7 days after the free gingival graft removal from the palate region. Of the 1,622 potentially relevant articles retrieved from the electronic databases, 16 RCTs were selected for qualitative analysis, and of these, 6 RCTs were included in the meta-analysis. RCTs showed a significant VAS reduction associated with the use of methods to enhance wound healing. The pooled estimates revealed a significant overall VAS reduction of 2.20 (95% Cl 2.32, 2.07) 7 days after surgery. The methods that presented the greatest reduction in the perception of pain were platelet-rich fibrin, hyaluronic acid, and autologous fibrin glue. Methods that enhance wound healing, including platelet-rich fibrin, hyaluronic acid, and autologous fibrin glue, can reduce pain perception after free gingival graft removal in the palate region. However, only 1 RCT investigated each approach, which hinders the conclusion regarding the best procedure to reduce the perception of pain.-
Descrição: dc.descriptionDepartment of Periodontology Dental Research Division Guarulhos University, SP-
Descrição: dc.descriptionDepartment of Dentistry Dental Research Division University of Taubaté, São Paulo-
Descrição: dc.descriptionDepartment of Periodontology Institute of Science and Technology São Paulo State University (UNESP), São José dos Campos-
Descrição: dc.descriptionThe Forsyth Institute The Forsyth Institute-
Descrição: dc.descriptionDepartment of Periodontology Institute of Science and Technology São Paulo State University (UNESP), São José dos Campos-
Formato: dc.format10-29-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Dental Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFree Gingival Graft-
Palavras-chave: dc.subjectPain-
Palavras-chave: dc.subjectPain Control-
Palavras-chave: dc.subjectPalatal Healing-
Palavras-chave: dc.subjectWound Healing-
Título: dc.titleIs there an effective way to control pain perception after free gingival graft removal? A systematic review and meta-analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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