HR-MAS NMR Metabolomics Profile of Vero Cells under the Influence of Virus Infection and nsP2 Inhibitor: A Chikungunya Case Study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorMedical School of Sao Jose do Rio Preto (FAMERP)-
Autor(es): dc.contributorForschungszentrum Jülich-
Autor(es): dc.contributorHeinrich-Heine-Universität Düsseldorf-
Autor(es): dc.creatorPeinado, Rafaela dos S.-
Autor(es): dc.creatorMartins, Lucas G.-
Autor(es): dc.creatorPacca, Carolina C.-
Autor(es): dc.creatorSaivish, Marielena V.-
Autor(es): dc.creatorBorsatto, Kelly C.-
Autor(es): dc.creatorNogueira, Maurício L.-
Autor(es): dc.creatorTasic, Ljubica-
Autor(es): dc.creatorArni, Raghuvir K.-
Autor(es): dc.creatorEberle, Raphael J.-
Autor(es): dc.creatorCoronado, Mônika A.-
Data de aceite: dc.date.accessioned2025-08-21T18:58:37Z-
Data de disponibilização: dc.date.available2025-08-21T18:58:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms25031414-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304095-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304095-
Descrição: dc.descriptionThe arbovirus Chikungunya (CHIKV) is transmitted by Aedes mosquitoes in urban environments, and in humans, it triggers debilitating symptoms involving long-term complications, including arthritis and Guillain-Barré syndrome. The development of antiviral therapies is relevant, as no efficacious vaccine or drug has yet been approved for clinical application. As a detailed map of molecules underlying the viral infection can be obtained from the metabolome, we validated the metabolic signatures of Vero E6 cells prior to infection (CC), following CHIKV infection (CV) and also upon the inclusion of the nsP2 protease inhibitor wedelolactone (CWV), a coumestan which inhibits viral replication processes. The metabolome groups evidenced significant changes in the levels of lactate, myo-inositol, phosphocholine, glucose, betaine and a few specific amino acids. This study forms a preliminary basis for identifying metabolites through HR-MAS NMR (High Resolution Magic Angle Spinning Nuclear Magnetic Ressonance Spectroscopy) and proposing the affected metabolic pathways of cells following viral infection and upon incorporation of putative antiviral molecules.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics Institute of Biosciences Languages and Exact Sciences (Ibilce—UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Organic Chemistry Institute of Chemistry University of Campinas (UNICAMP)-
Descrição: dc.descriptionVirology Research Laboratory Medical School of Sao Jose do Rio Preto (FAMERP)-
Descrição: dc.descriptionInstitute of Biological Information Processing IBI-7: Structural Biochemistry Forschungszentrum Jülich-
Descrição: dc.descriptionInstitut für Physikalische Biologie Heinrich-Heine-Universität Düsseldorf-
Descrição: dc.descriptionMultiuser Center for Biomolecular Innovation Department of Physics Institute of Biosciences Languages and Exact Sciences (Ibilce—UNESP), Sao Paulo-
Descrição: dc.descriptionFAPESP: 2013/21719-3-
Descrição: dc.descriptionFAPESP: 2017/13341-1-
Descrição: dc.descriptionFAPESP: 2018/06510-4-
Descrição: dc.descriptionFAPESP: 2018/15083-2-
Descrição: dc.descriptionFAPESP: 2018/24069-3-
Descrição: dc.descriptionFAPESP: 2020/03639-6-
Descrição: dc.descriptionFAPESP: 2020/08615-8-
Descrição: dc.descriptionFAPESP: 2020/12875-5-
Descrição: dc.descriptionFAPESP: 2023/09590-7-
Descrição: dc.descriptionCNPq: 309940/2019-2-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject1H-NMR-
Palavras-chave: dc.subjectarbovirus-
Palavras-chave: dc.subjectChikungunya-
Palavras-chave: dc.subjectmetabolomics-
Palavras-chave: dc.subjectVero cells-
Palavras-chave: dc.subjectwedelolactone-
Título: dc.titleHR-MAS NMR Metabolomics Profile of Vero Cells under the Influence of Virus Infection and nsP2 Inhibitor: A Chikungunya Case Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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