Creeping fat and gut microbiota in Crohn’s disease

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorBotucatu Technology Park-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorQuaglio, Ana E.V.-
Autor(es): dc.creatorMagro, Daniéla O.-
Autor(es): dc.creatorImbrizi, Marcello-
Autor(es): dc.creatorDe Oliveira, Ellen C.S.-
Autor(es): dc.creatorDi Stasi, Luiz C.-
Autor(es): dc.creatorSassaki, Ligia Y.-
Data de aceite: dc.date.accessioned2025-08-21T15:24:51Z-
Data de disponibilização: dc.date.available2025-08-21T15:24:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3748/wjg.v31.i1.102042-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304093-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304093-
Descrição: dc.descriptionIn this article, we explored the role of adipose tissue, especially mesenteric adipose tissue and creeping fat, and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease (CD). CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract, influenced by genetic predisposition, gut microbiota dysbiosis, and environmental factors. Gut microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of CD. Further, visceral adipose tissue, particularly creeping fat, a mesenteric adipose tissue characterized by hypertrophy and fibrosis, has been implicated in CD pathogenesis, inflammation, and fibrosis. The bacteria from the gut microbiota may translocate into mesenteric adipose tissue, contributing to the formation of creeping fat and influencing CD progression. Although creeping fat may be a protective barrier against bacterial invasion, its expansion can damage adjacent tissues, leading to complications. Modulating gut microbiota through interventions such as fecal microbiota transplantation, probiotics, and prebiotics has shown potential in managing CD. However, more research is needed to clarify the mechanisms linking gut dysbiosis, creeping fat, and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.-
Descrição: dc.descriptionVerum Ingredients Botucatu Technology Park, Botucatu-
Descrição: dc.descriptionDepartment of Surgery Faculty of Medical Sciences State University of Campinas, Campinas-
Descrição: dc.descriptionDepartment of Gastroenterology Faculty of Medical Sciences University of Campinas, Campinas-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University, Botucatu-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University, Botucatu-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School São Paulo State University, Botucatu-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University, Botucatu-
Idioma: dc.languageen-
Relação: dc.relationWorld Journal of Gastroenterology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCreeping fat-
Palavras-chave: dc.subjectCrohn’s disease-
Palavras-chave: dc.subjectGut microbiota-
Palavras-chave: dc.subjectInflammatory bowel disease-
Palavras-chave: dc.subjectMesenteric adipose tissue-
Título: dc.titleCreeping fat and gut microbiota in Crohn’s disease-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.