Heterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCenter for the Study of Venoms and Venomous Animals (CEVAP)-
Autor(es): dc.creatorMuller, Kevin Silva-
Autor(es): dc.creatorTibúrcio, Felipe Cantore-
Autor(es): dc.creatorJunior, Rui Seabra Ferreira-
Autor(es): dc.creatorBarraviera, Benedito-
Autor(es): dc.creatorMatheus, Selma Maria Michelin-
Data de aceite: dc.date.accessioned2025-08-21T20:44:51Z-
Data de disponibilização: dc.date.available2025-08-21T20:44:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-9199-JVATITD-2023-0060-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304056-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304056-
Descrição: dc.descriptionNerve injuries present a substantial challenge within the medical domain due to their prevalent occurrence and significant impact. In nerve injuries, a range of physiopathological and metabolic responses come into play to stabilize and repair the resulting damage. A critical concern arises from the disruption of connections at neuromuscular junctions, leading to profound degeneration and substantial loss of muscle function, thereby hampering motor tasks. While end-to-end neurorrhaphy serves as the established technique for treating peripheral nerve injuries, achieving comprehensive morphofunctional recovery remains a formidable challenge. In pursuit of enhancing the repair process, alternative and supportive methods are being explored. A promising candidate is the utilization of heterologous fibrin biopolymer, a sealant devoid of human blood components. Notably, this biopolymer has showcased its prowess in establishing a stable and protective microenvironment at the site of use in multiple scenarios of regenerative medicine. Hence, this scoping review is directed towards assessing the effects of associating heterologous fibrin biopolymer with neurorrhaphy to treat nerve injuries, drawing upon findings from prior studies disseminated through PubMed/ MEDLINE, Scopus, and Web of Science databases. Further discourse delves into the intricacies of the biology of neuromuscular junctions, nerve injury pathophysiology, and the broader utilization of fibrin sealants in conjunction with sutures for nerve reconstruction procedures. The association of the heterologous fibrin biopolymer with neurorrhaphy emerges as a potential avenue for surmounting the limitations associated with traditional sealants while also mitigating degeneration in nerves, muscles, and NMJs post-injury, thereby fostering a more conducive environment for subsequent regeneration. Indeed, queries arise regarding the long-term regenerative potential of this approach and its applicability in reconstructive surgeries for human nerve injuries.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology São Paulo State University (UNESP) Botucatu Institute of Biosciences, SP-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCenter for Translational Sciences and Biopharmaceuticals Development (CTS) Center for the Study of Venoms and Venomous Animals (CEVAP), SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology São Paulo State University (UNESP) Botucatu Institute of Biosciences, SP-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2022/0755-1-
Descrição: dc.descriptionCNPq: 303224/2018-5-
Descrição: dc.descriptionCNPq: 306339/2020-0-
Idioma: dc.languageen-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFibrin sealant-
Palavras-chave: dc.subjectNervous system-
Palavras-chave: dc.subjectNeurorrhaphy-
Palavras-chave: dc.subjectRegenerative medicine-
Título: dc.titleHeterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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