Plasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorEuropean Bioinformatics Institute-
Autor(es): dc.creatorViana-Mattioli, Sarah-
Autor(es): dc.creatorFonseca-Alaniz, Miriam Helena-
Autor(es): dc.creatorPinheiro-de-Sousa, Iguaracy-
Autor(es): dc.creatorJunior, Ricardo Rosa-
Autor(es): dc.creatorMastella, Moises Henrique-
Autor(es): dc.creatorde Carvalho Cavalli, Ricardo-
Autor(es): dc.creatorSandrim, Valeria Cristina-
Data de aceite: dc.date.accessioned2025-08-21T21:04:58Z-
Data de disponibilização: dc.date.available2025-08-21T21:04:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-025-88902-8-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304035-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304035-
Descrição: dc.descriptionPreeclampsia (PE) is a challenge in maternal healthcare due to its complex nature, characterized by high blood pressure, protein in the urine, and damage to various organs. There is evidence linking PE to endothelial dysfunction (ED), triggered by substances released from an oxygen-deprived placenta. Previous in vitro studies have not considered the impact of in vivo elements, such as the different patterns of blood flow, and laminar (LSS) vs. oscillatory (OSS) shear stress, on the development of ED. We investigated the impact of plasma from healthy pregnant women (HP), subjects with gestational hypertension (GH), and PE patients on global gene expression of human coronary endothelial cells (HCAECs) under LSS and OSS. Our findings revealed a unique transcriptional profile of endothelial cells induced by plasma incubation in LSS. Notably, OSS resulted in similar transcriptomes irrespective of plasma treatment. Under LSS, GH plasma resulted in a proliferative profile, whereas PE plasma was linked to pro-inflammatory and antioxidant profiles compared to HP plasma. Our findings demonstrate that shear stress levels influence the endothelial cell transcriptome in response to plasma from hypertensive pregnancy patients. Both PE and GH can induce endothelial dysfunction under atheroprotective LSS, with a more significant effect observed with PE-derived plasma.-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubião Júnior, SP-
Descrição: dc.descriptionLaboratorio de Genetica e Cardiologia Molecular Instituto do Coracao (InCor) Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo, SP-
Descrição: dc.descriptionEuropean Molecular Biology Laboratory European Bioinformatics Institute-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Hospital das Clínicas Medical School of Ribeirão Preto University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubião Júnior, SP-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndothelial dysfunction-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectPregnancy-
Palavras-chave: dc.subjectShear stress-
Título: dc.titlePlasma from hypertensive pregnancy patients induce endothelial dysfunction even under atheroprotective shear stress-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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