Mucoadhesive liquid crystal precursor system for photodynamic therapy of oral cancer mediated by methylene blue

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBalian, Giovana Maria Fioramonti Calixto-
Autor(es): dc.creatorLuiz, Marcela Tavares-
Autor(es): dc.creatorFilippo, Leonardo Delello Di-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T15:37:49Z-
Data de disponibilização: dc.date.available2025-08-21T15:37:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2023.103739-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304025-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304025-
Descrição: dc.descriptionOral cancer is one of the most prevalent types of cancer head and neck cancers worldwide. Photodynamic therapy (PDT) has demonstrated great potential against cancers, reducing long-term morbidity. In this study, we investigated the incorporation of methylene blue (MB) in a mucoadhesive liquid crystal precursor system (LCPS) for oral cancer treatment. The photostability and the in vitro release, permeation, and retention profile of MB-loaded LCPS (MB-LCPS) were investigated, as well as its in vitro PDT activity against normal (HaCaT) and tumoral (HSC-3) cell lines. LCPS increased the photostability of MB and exhibited a prolonged release profile of MB. In addition, LCPS increased the retention of MB in the porcine esophageal mucosa by around 3 times higher than the MB solution. The retention of MB in LCPS was around 2 times greater than its permeability, which is suitable for guaranteeing the maintenance of the therapy in the oral cavity. In vitro cytotoxicity assay indicated that MB-LCPS increased the antitumoral activity of MB after 20 min of irradiation at 660 nm and 12.5 J/cm2. The results obtained suggest that the developed formulation is an interesting strategy for the potential application in the treatment of oral cancer by PDT.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biosciences Piracicaba Dental School University of Campinas – UNICAMP, Piracicaba-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University - UNESP, Araraquara-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University - UNESP, Araraquara-
Descrição: dc.descriptionCNPq: # 465687/2014-8-
Descrição: dc.descriptionFAPESP: #2014/50928-2-
Descrição: dc.descriptionFAPESP: 2013/01565-1-
Descrição: dc.descriptionFAPESP: 2016/06337-5-
Descrição: dc.descriptionFAPESP: 2019/07245-5-
Descrição: dc.descriptionFAPESP: 2021/04007-6-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBuccal route-
Palavras-chave: dc.subjectDrug delivery system-
Palavras-chave: dc.subjectLiquid crystalline system-
Palavras-chave: dc.subjectPhotodynamic Therapy-
Palavras-chave: dc.subjectPhotosensitizer-
Título: dc.titleMucoadhesive liquid crystal precursor system for photodynamic therapy of oral cancer mediated by methylene blue-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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