Pfaffia paniculata Extract, a Potential Antimicrobial Agent against Candida spp., Pseudomonas aeruginosa, and Streptococcus mutans Biofilms

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Autor(es): dc.contributorUniversity of Lyon-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPaulista University-
Autor(es): dc.contributorUniversity of Leeds-
Autor(es): dc.contributorEstrada Municipal do Pinhão do Borba-
Autor(es): dc.creatorMiranda, Diego Garcia-
Autor(es): dc.creatorRamos, Lucas de Paula-
Autor(es): dc.creatorAttik, Nina-
Autor(es): dc.creatorPereira, Thaís Cristine-
Autor(es): dc.creatorOliveira, Luciane Dias de-
Autor(es): dc.creatorMarcucci, Maria Cristina-
Autor(es): dc.creatorRodrigues, Flavia Pires-
Autor(es): dc.creatorBack Brito, Graziella Nuernberg-
Autor(es): dc.creatorCarrouel, Florence-
Data de aceite: dc.date.accessioned2025-08-21T20:56:29Z-
Data de disponibilização: dc.date.available2025-08-21T20:56:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/microorganisms12061165-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304024-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304024-
Descrição: dc.descriptionThe World Health Organization (WHO) has prioritized developing new drugs against specific bacteria and fungi, such as Enterobacteriaceae and Candida spp. While Pfaffia paniculata is commonly called the “cure-everything”, its scientifically proven benefits are limited to anti-inflammatory and antioxidant actions. Therefore, this study aims to determine the spectrum of antimicrobial activity of Pfaffia paniculata and assess its cytotoxicity. Thus, broth microdilution test was conducted according to the CLSI M7-A9 and M27-A3 reference methods. After screening, microbial species with minimum inhibitory concentration (MIC) values were selected for biofilm tests. These tests evaluated biomass using the crystal violet (CV) test, metabolic activity using the MTT assay, and structural analysis via Scanning Electron Microscopy (SEM). Cytotoxicity was evaluated in human gingival fibroblasts (FMM-1). There were reductions of 29.4 and 42.7% in CV and MTT assays for Candida spp. biofilm. S. mutans and P. aeruginosa biofilms showed a decrease of 15.7 and 28.6%, respectively. Cell viability tests indicated 55.1, 56.9, and 65.5% of viability after contact with 1.93, 0.96, and 0.48 mg/mL of the extract, respectively. The P. paniculata extract showed antimicrobial action, displayed MIC values, and antibiofilm action on P. aeruginosa, S. mutans, and C. albicans. The cytotoxicity on the FMM-1 cell line was dose-dependent. Therefore, P. paniculata extract holds significant potential for developing new drugs.-
Descrição: dc.descriptionMultimaterials and Interfaces Laboratory (LMI) CNRS UMR 5615 University Claude Bernard Lyon 1 University of Lyon, 6 rue Victor Grignard-
Descrição: dc.descriptionFaculté d’Odontologie University Claude Bernard Lyon 1 University of Lyon, 7 rue Guillaume Paradin-
Descrição: dc.descriptionLaboratory “Health Systemic Process” (P2S) UR4129 Faculty of Medicine Laennec University Claude Bernard Lyon 1 University of Lyon, 7 rue Guillaume Paradin-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University, Francisco José Longo 777, SP-
Descrição: dc.descriptionDepartment of Health Sciences Paulista University, Highway President Dutra km 157, SP-
Descrição: dc.descriptionOral Biology Division School of Dentistry Faculty of Medicine and Health University of Leeds-
Descrição: dc.descriptionChristian Life University Foundation Estrada Municipal do Pinhão do Borba, SP-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University, Francisco José Longo 777, SP-
Idioma: dc.languageen-
Relação: dc.relationMicroorganisms-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantibacterial agents-
Palavras-chave: dc.subjectantifungal agents-
Palavras-chave: dc.subjectBrazilian ginseng-
Palavras-chave: dc.subjectCandidaspp-
Palavras-chave: dc.subjectherbal medicine-
Palavras-chave: dc.subjectPfaffia paniculata-
Título: dc.titlePfaffia paniculata Extract, a Potential Antimicrobial Agent against Candida spp., Pseudomonas aeruginosa, and Streptococcus mutans Biofilms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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