Intraoral CD30+ T-Cell Lymphoproliferative Disorder with Lymphomatoid Papulosis Type C Features Mimics Lymphoma Histopathologically and Immunohistochemically

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentro Universitário Estácio Ribeirão Preto-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorBarbeiro, Camila Oliveira-
Autor(es): dc.creatorSilveira, Heitor Albergoni-
Autor(es): dc.creatorBarbeiro, Roberto Henrique-
Autor(es): dc.creatorMartins, Karina Helen-
Autor(es): dc.creatorBufalino, Andreia-
Autor(es): dc.creatorChahud, Fernando-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Data de aceite: dc.date.accessioned2025-08-21T21:53:23Z-
Data de disponibilização: dc.date.available2025-08-21T21:53:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12105-024-01664-z-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/304008-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/304008-
Descrição: dc.descriptionBackground: Previous studies have shown that at least a of intraoral eosinophilic ulcer is best classified as a CD30 + T-cell lymphoproliferative disorder (LPD), with histopathology reminiscent of lymphomatoid papulosis (LyP) of the skin. Microscopically, a mixed population of inflammatory cells, often including eosinophils and varying numbers of atypical lymphoid cells, frequently expressing CD30, is typical for LyP, whose clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement. To date, about 27 intraoral LyP cases have been reported. Of them, 7 cases were diagnosed as LyP type C, which is frequently confused with anaplastic large cell lymphoma (ALCL) on histopathology. Methods: A 60-year-old male was referred for a one-month history of a tongue ulcer. Results: Microscopy showed numerous subepithelial atypical large lymphoid cells, which expressed CD4 (with partial loss of CD3, CD5, and CD7), CD8 (few cells), CD30 (about 50%, in non-diffuse pattern with size variability), TIA-1, and Ki-67 (85%), without staining for CD56, ALK, LMP1, and EBER1/2, concerning for a diagnosis of ALCL. However, after three weeks, the lesion completely healed. Conclusion: We present here a rare case of intraoral CD30+ T-cell LPD that we believe is the oral counterpart of cutaneous LyP type C.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (Unesp)-
Descrição: dc.descriptionCentro Universitário Estácio Ribeirão Preto, SP-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School University of São Paulo (FORP/USP), SP-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São Paulo, SP-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (Unesp)-
Descrição: dc.descriptionFAPESP: (2016/11419-0; 2022/07479-9-
Descrição: dc.descriptionCNPq: (304241/2021-0)-
Descrição: dc.descriptionFAPESP: 2022/12760-9)-
Idioma: dc.languageen-
Relação: dc.relationHead and Neck Pathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnaplastic large cell lymphoma-
Palavras-chave: dc.subjectDifferential diagnosis-
Palavras-chave: dc.subjectLymphomatoid papulosis type C-
Palavras-chave: dc.subjectLymphoproliferative disorder-
Palavras-chave: dc.subjectOral cavity-
Título: dc.titleIntraoral CD30+ T-Cell Lymphoproliferative Disorder with Lymphomatoid Papulosis Type C Features Mimics Lymphoma Histopathologically and Immunohistochemically-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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