Identifying New Contributors to Brain Metastasis in Lung Adenocarcinoma: A Transcriptomic Meta-Analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBritish Columbia Cancer Research Institute-
Autor(es): dc.contributorBritish Columbia Children’s Hospital Research Institute-
Autor(es): dc.contributorAberystwyth University-
Autor(es): dc.creatorSouza, Vanessa G. P.-
Autor(es): dc.creatorForder, Aisling-
Autor(es): dc.creatorTelkar, Nikita-
Autor(es): dc.creatorStewart, Greg L.-
Autor(es): dc.creatorCarvalho, Robson F.-
Autor(es): dc.creatorMur, Luis A. J.-
Autor(es): dc.creatorLam, Wan L.-
Autor(es): dc.creatorReis, Patricia P.-
Data de aceite: dc.date.accessioned2025-08-21T21:26:46Z-
Data de disponibilização: dc.date.available2025-08-21T21:26:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cancers15184526-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303975-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303975-
Descrição: dc.descriptionLung tumors frequently metastasize to the brain. Brain metastasis (BM) is common in advanced cases, and a major cause of patient morbidity and mortality. The precise molecular mechanisms governing BM are still unclear, in part attributed to the rarity of BM specimens. In this work, we compile a unique transcriptomic dataset encompassing RNA-seq, microarray, and single-cell analyses from BM samples obtained from patients with lung adenocarcinoma (LUAD). By integrating this comprehensive dataset, we aimed to enhance understanding of the molecular landscape of BM, thereby facilitating the identification of novel and efficient treatment strategies. We identified 102 genes with significantly deregulated expression levels in BM tissues, and discovered transcriptional alterations affecting the key driver ‘hub’ genes CD69 (a type II C-lectin receptor) and GZMA (Granzyme A), indicating an important role of the immune system in the development of BM from primary LUAD. Our study demonstrated a BM-specific gene expression pattern and revealed the presence of dendritic cells and neutrophils in BM, suggesting an immunosuppressive tumor microenvironment. These findings highlight key drivers of LUAD-BM that may yield therapeutic targets to improve patient outcomes.-
Descrição: dc.descriptionMolecular Oncology Laboratory Experimental Research Unit (UNIPEX) Faculty of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionBritish Columbia Cancer Research Institute-
Descrição: dc.descriptionBritish Columbia Children’s Hospital Research Institute-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Life Science Aberystwyth University-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionMolecular Oncology Laboratory Experimental Research Unit (UNIPEX) Faculty of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationCancers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbioinformatics-
Palavras-chave: dc.subjectbrain metastasis-
Palavras-chave: dc.subjectimmune cell-
Palavras-chave: dc.subjectlung cancer-
Palavras-chave: dc.subjecttumor microenvironment (TME)-
Título: dc.titleIdentifying New Contributors to Brain Metastasis in Lung Adenocarcinoma: A Transcriptomic Meta-Analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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