Cowpea bean β-vignin-derived AQQSY peptide exerts an anticancer effect by inducing cell cycle arrest in the G0/G1 phase and modulating apoptotic signals

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Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversity of Illinois at Urbana-Champaign-
Autor(es): dc.contributorGeneral Rodrigo Octávio Jordão Ramos Avenue-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOliveira Philadelpho, Biane-
Autor(es): dc.creatordos Santos, Johnnie Elton Machado-
Autor(es): dc.creatorElaine Davis, Emily-
Autor(es): dc.creatorBarros de Cerqueira e Silva, Mariana-
Autor(es): dc.creatorMaffud Cilli, Eduardo-
Autor(es): dc.creatorde Souza Ferreira, Ederlan-
Autor(es): dc.creatorGonzález de Mejia, Elvira-
Data de aceite: dc.date.accessioned2025-08-21T18:09:26Z-
Data de disponibilização: dc.date.available2025-08-21T18:09:26Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jff.2024.106498-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303951-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303951-
Descrição: dc.descriptionThe anticancer effect of digested β-vignin and pure peptides from cowpea beans was investigated in cultivated human colon cancer cells. The effect of AQQSY on the cell cycle was similar to that of palbociclib, suggesting that AQQSY may function as a CDK-6-targeting agent. AQQSY peptide reduced the p-Rb/Rb ratio and induced apoptosis through an increase of Bax/Bcl-2 ratio, a decrease of XIAP, and activation of caspase-3. VIPASY peptide showed the potential to induce apoptosis through an increase in Bax/Bcl-2 ratio. The combination of VIPASY and AQQSY with palbociclib caused an additive effect on cell inhibition. Treatment with selected peptides from β-vignin digest caused cell cycle arrest by upregulation of p16 and apoptosis by increasing Bax/Bcl-2 ratio and caspase-8. The peptides and β-vignin digest treatments were more selective for cancer cells than the drugs. Additional research is necessary in vivo to understand the mechanisms of cowpea β-vignin-derived peptides in CRC treatment.-
Descrição: dc.descriptionSchool of Pharmacy Federal University of Bahia, Barão de Jeremoabo Street, BA-
Descrição: dc.descriptionUniversity of Illinois at Urbana-Champaign Department Food Science and Human Nutrition, 228 Edward R Madigan Lab, IL-
Descrição: dc.descriptionSchool of Pharmacy Federal University of Amazonas General Rodrigo Octávio Jordão Ramos Avenue, Amazonas-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Rua Prof. Francisco Degni, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Rua Prof. Francisco Degni, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Foods-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBax/Bcl-2. HCT-116 cells-
Palavras-chave: dc.subjectBioactive peptides-
Palavras-chave: dc.subjectCell cycle arrest-
Palavras-chave: dc.subjectDocking-
Palavras-chave: dc.subjectVigna unguiculata-
Título: dc.titleCowpea bean β-vignin-derived AQQSY peptide exerts an anticancer effect by inducing cell cycle arrest in the G0/G1 phase and modulating apoptotic signals-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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