Improvement of DOPA-Melanin Production by Aspergillus nidulans Using Eco-Friendly and Inexpensive Substrates

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCampanhol, Beatriz Silva-
Autor(es): dc.creatorRibeiro, Beatriz Dias-
Autor(es): dc.creatorCasellato, Fernando-
Autor(es): dc.creatorMedina, Kelly Johana Dussán-
Autor(es): dc.creatorSponchiado, Sandra Regina Pombeiro-
Data de aceite: dc.date.accessioned2025-08-21T16:26:56Z-
Data de disponibilização: dc.date.available2025-08-21T16:26:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jof9070714-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303943-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303943-
Descrição: dc.descriptionFungal pigments, including melanin, are recognized as promising materials for biomedical, environmental, and technological applications. In previous studies, we have demonstrated that the DOPA-melanin produced by the MEL1 mutant of Aspergillus nidulans exhibits antioxidant, anti-inflammatory, and antimicrobial activities without any cytotoxic or mutagenic effects, suggesting its potential use in pharmaceuticals. In order to increase the yield of this pigment and reduce the costs of its large-scale production, the present study aimed to evaluate agro-industrial by-products, sugarcane molasses, vinasse, and corn steep liquor as inexpensive substrates for fungal growth using experimental design methodology. According to the results obtained, the optimal composition of the culture medium was 0.81% (v/v) vinasse and 1.62% (w/v) glucose, which promoted a greater production of melanin (225.39 ± 4.52 mg g−1 of biomass), representing a 2.25-fold increase compared with the condition before optimization (100.32 mg.g−1 of biomass). Considering the amount of biomass obtained in the optimized condition, it was possible to obtain a total melanin production of 1 g L−1. Therefore, this formulation of a less complex and low-cost culture medium composition makes the large-scale process economically viable for future biotechnological applications of melanin produced by A. nidulans.-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Engineering Physics and Mathematics Institute of Chemistry Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionBioenergy Research Institute (IPBEN) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Engineering Physics and Mathematics Institute of Chemistry Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionBioenergy Research Institute (IPBEN) São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Fungi-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAspergillus nidulans-
Palavras-chave: dc.subjectcorn steep liquor-
Palavras-chave: dc.subjectmelanin-
Palavras-chave: dc.subjectmolasses-
Palavras-chave: dc.subjectoptimization-
Palavras-chave: dc.subjectpigment-
Palavras-chave: dc.subjectvinasse-
Título: dc.titleImprovement of DOPA-Melanin Production by Aspergillus nidulans Using Eco-Friendly and Inexpensive Substrates-
Tipo de arquivo: dc.typelivro digital-
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