Implementation of multiomic mass spectrometry approaches for the evaluation of human health following environmental exposure

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorPurdue University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFerreira, Christina R.-
Autor(es): dc.creatorLima Gomes, Paulo Clairmont F. de-
Autor(es): dc.creatorRobison‡, Kiley Marie-
Autor(es): dc.creatorCooper, Bruce R.-
Autor(es): dc.creatorShannahan, Jonathan H.-
Data de aceite: dc.date.accessioned2025-08-21T20:31:50Z-
Data de disponibilização: dc.date.available2025-08-21T20:31:50Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-26-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d3mo00214d-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303877-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303877-
Descrição: dc.descriptionOmics analyses collectively refer to the possibility of profiling genetic variants, RNA, epigenetic markers, proteins, lipids, and metabolites. The most common analytical approaches used for detecting molecules present within biofluids related to metabolism are vibrational spectroscopy techniques, represented by infrared, Raman, and nuclear magnetic resonance (NMR) spectroscopies and mass spectrometry (MS). Omics-based assessments utilizing MS are rapidly expanding and being applied to various scientific disciplines and clinical settings. Most of the omics instruments are operated by specialists in dedicated laboratories; however, the development of miniature portable omics has made the technology more available to users for field applications. Variations in molecular information gained from omics approaches are useful for evaluating human health following environmental exposure and the development and progression of numerous diseases. As MS technology develops so do statistical and machine learning methods for the detection of molecular deviations from personalized metabolism, which are correlated to altered health conditions, and they are intended to provide a multi-disciplinary overview for researchers interested in adding multiomic analysis to their current efforts. This includes an introduction to mass spectrometry-based omics technologies, current state-of-the-art capabilities and their respective strengths and limitations for surveying molecular information. Furthermore, we describe how knowledge gained from these assessments can be applied to personalized medicine and diagnostic strategies.-
Descrição: dc.descriptionPurdue Metabolite Profiling Facility Purdue University-
Descrição: dc.descriptionSao Paulo State University Julio de Mesquita Filho Institute of Chemistry, Sao Paulo-
Descrição: dc.descriptionSchool of Health Sciences College of Health and Human Sciences Purdue University-
Descrição: dc.descriptionSao Paulo State University Julio de Mesquita Filho Institute of Chemistry, Sao Paulo-
Formato: dc.format296-321-
Idioma: dc.languageen-
Relação: dc.relationMolecular Omics-
???dc.source???: dc.sourceScopus-
Título: dc.titleImplementation of multiomic mass spectrometry approaches for the evaluation of human health following environmental exposure-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.