Magnetic particle spray mass spectrometry for the determination of beta-blockers in plasma samples

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Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorFederal University of Rio Grande-
Autor(es): dc.contributorFederal University of Juiz de Fora-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Castilho Alves Morais, Elizângela Maria-
Autor(es): dc.creatorMendes, Tássia Venga-
Autor(es): dc.creatorArnoni, Estela Domingos-
Autor(es): dc.creatorGorup, Luiz Fernando-
Autor(es): dc.creatorRosa, Mariana Azevedo-
Autor(es): dc.creatorMoreira, Ailton José-
Autor(es): dc.creatorFigueiredo, Eduardo Costa-
Data de aceite: dc.date.accessioned2025-08-21T20:53:19Z-
Data de disponibilização: dc.date.available2025-08-21T20:53:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00604-024-06698-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303855-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303855-
Descrição: dc.descriptionMagnetic particle spray mass spectrometry (MPS-MS), an innovative ambient ionization technique proposed by our research group, was employed to determine beta-blockers in human plasma samples. A dispersive solid phase extraction of atenolol, metoprolol, labetalol, propranolol, nadolol, and pindolol was carried out using magnetic molecularly imprinted polymer (M-MIP) particles that were attached to the tip of a metal probe, which was placed in the mass spectrometer inlet. A solvent (1% formic acid in methanol) was dispensed on the particles, and the Taylor cone was formed around them (in high voltage). The analytes were desorbed/ionized and determined by a triple quadrupole mass spectrometer. M-MIP was synthesized with oxprenolol as a pseudo-template, demonstrating good selectivity to beta-blockers compared with no-analog molecules, with an adsorption process occurring in monolayers, according to isotherm studies. Kinetic experiments indicated chemisorption as the predominant M-MIP/analyte interaction. The analytical curves were linear (R2 > 0.98), and the limit of quantification was 3 µg L−1 for all the analytes. Limits of detection ranged from 0.64 to 2.41 µg L−1. Precisions (relative standard deviation) and accuracies (relative error) ranged from 3.95 to 21.20% and -17.05 to 18.93%, respectively. MPS-MS proved to be a simple, sensitive, and advantageous technique compared with conventional approaches. The analyses were fast, requiring no chromatographic separation and without ionic suppression. The method is aligned with green chemistry principles, requiring minimal sample, solvent, and sorbent amounts. MPS-MS successfully integrates sample preparation and ambient ionization mass spectrometry and holds great potential for application with other sorbents, samples, and analytes. Graphical Abstract: (Figure presented.)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Toxicant and Drug Analyses Faculty of Pharmaceutical Sciences Federal University of Alfenas, MG-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Alfenas, MG-
Descrição: dc.descriptionDepartment of Chemistry Interdiscipli5nary Laboratory of Electrochemistry and Ceramics (LIEC) Federal University of São Carlos, SP-
Descrição: dc.descriptionSchool of Chemistry and Food Science Federal University of Rio Grande, RS-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Juiz de Fora, MG-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationMicrochimica Acta-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmbient ionization-
Palavras-chave: dc.subjectDispersive solid phase extraction-
Palavras-chave: dc.subjectMagnetic particle spray mass spectrometry-
Palavras-chave: dc.subjectMagnetic sorbent-
Palavras-chave: dc.subjectMolecularly imprinted polymers-
Título: dc.titleMagnetic particle spray mass spectrometry for the determination of beta-blockers in plasma samples-
Tipo de arquivo: dc.typelivro digital-
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