Smart Delivery of Biomolecules Interfering with Peri-Implant Repair in Osteoporotic Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPaludetto, Laura Vidoto-
Autor(es): dc.creatorMonteiro, Naara Gabriela-
Autor(es): dc.creatorBreseghello, Isadora-
Autor(es): dc.creatorde Souza Batista, Fábio Roberto-
Autor(es): dc.creatorAntoniali, Cristina-
Autor(es): dc.creatorLisboa-Filho, Paulo Noronha-
Autor(es): dc.creatorOkamoto, Roberta-
Data de aceite: dc.date.accessioned2025-08-21T17:35:04Z-
Data de disponibilização: dc.date.available2025-08-21T17:35:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms25168963-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/303642-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/303642-
Descrição: dc.descriptionBisphosphonates are widely used for the treatment of postmenopausal osteoporosis; however, they cause several long-term side effects, necessitating the investigation of local ways to improve osseointegration in compromised bone tissue. The purpose of this study was to evaluate peri-implant bone repair using implants functionalized with zoledronic acid alone (OVX ZOL group, n = 11), zoledronic acid + teriparatide (OVX ZOL + TERI group, n = 11), and zoledronic acid + ruterpy (OVX ZOL + TERPY group, n = 11) compared to the control group (OVX CONV, n = 11). Analyses included computer-assisted microtomography, qualitative histologic analysis, and real-time PCR analysis. Histologically, all functionalized surfaces improved peri-implant repair, with the OVX ZOL + TERI group standing out. Similar results were found in computerized microtomography analysis. In real-time PCR analysis, however, the OVX ZOL and OVX ZOL + TERPY groups showed better results for bone formation, with the OVX ZOL + TERPY group standing out, while there were no statistical differences between the OVX CONV and OVX ZOL + TERI groups for the genes studied at 28 postoperative days. Nevertheless, all functionalized groups showed a reduced rate of bone resorption. In short, all surface functionalization groups outperformed the control group, with overall better results for the OVX ZOL + TERI group.-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Descrição: dc.descriptionDepartment of Physics and Meteorology Bauru Sciences School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Descrição: dc.descriptionDepartment of Physics and Meteorology Bauru Sciences School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdental implants-
Palavras-chave: dc.subjectosteoporosis-
Palavras-chave: dc.subjectruterpy-
Palavras-chave: dc.subjectteriparatide-
Palavras-chave: dc.subjectzoledronic acid-
Título: dc.titleSmart Delivery of Biomolecules Interfering with Peri-Implant Repair in Osteoporotic Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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